Cortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomas

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dc.contributor.authorAmbrosio, Eliane Papa [UNESP]
dc.contributor.authorRosa, Fabiola Encinas [UNESP]
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorRios Villacis, Rolando Andre
dc.contributor.authorCoudry, Renata de Almeida
dc.contributor.authorTagliarini, José Vicente [UNESP]
dc.contributor.authorSoares, Fernando Augusto
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionHosp AC Camargo Fund Antonio Prudente
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAC Camargo Hosp
dc.date.accessioned2014-05-20T13:38:51Z
dc.date.available2014-05-20T13:38:51Z
dc.date.issued2011-09-01
dc.description.abstractThe cortactin gene, mapped at 11q13, has been associated with an aggressive clinical course in many cancers because of its function of invasiveness. This study evaluated CTTN protein and its prognostic value in the deep invasive front and superficial areas of laryngeal squamous cell carcinomas. The transcript expression levels were evaluated in a subset of cases. Overexpression of CTTN cytoplasmatic protein (80% of cases in both the deep invasive front and superficial areas) and transcript (30% of samples) was detected in a significant number of cases. In more than 20% of cases, observation verified membrane immunostaining in the deep invasive front and superficial areas. Perineural invasion was significantly associated with N stage and recurrence (P = .0058 and P = .0037, respectively). Higher protein expression levels were correlated with perineural invasion (P = .004) in deep invasive front cells, suggesting that this area should be considered a prognostic tool in laryngeal carcinomas. Although most cases had moderate to strong CTTN expression on the tumor surface, 2 sets of cases revealed a differential expression pattern in the deep invasive front. A group of cases with absent to weak expression of CTTN in the deep invasive front showed good prognosis parameters, and a second group with moderate to strong expression of CTTN were associated with an unfavorable prognosis, suggesting an association with worse outcome. Taken together, these results suggest that the deep invasive front might be considered a grading system in laryngeal carcinomas and that cortactin is a putative marker of worse outcome in the deep invasive front of laryngeal carcinomas. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationHosp AC Camargo Fund Antonio Prudente, NeoGene Lab, AC Camargo Canc Treatment & Res Ctr, BR-01509010 São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Inst Biosci, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Fac Med, Dept Ophtalmol & Otorhinolaryngol, São Paulo, Brazil
dc.description.affiliationAC Camargo Hosp, Dept Anat Pathol, São Paulo, Brazil
dc.description.affiliationAC Camargo Hosp, Dept Head & Neck Surg & Otorhinolaryngol, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Dept Urol, Fac Med, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Inst Biosci, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Fac Med, Dept Ophtalmol & Otorhinolaryngol, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dept Urol, Fac Med, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1221-1229
dc.identifierhttp://dx.doi.org/10.1016/j.humpath.2010.05.030
dc.identifier.citationHuman Pathology. Philadelphia: W B Saunders Co-elsevier Inc, v. 42, n. 9, p. 1221-1229, 2011.
dc.identifier.doi10.1016/j.humpath.2010.05.030
dc.identifier.issn0046-8177
dc.identifier.lattes2259986546265579
dc.identifier.lattes0585723113037140
dc.identifier.urihttp://hdl.handle.net/11449/13474
dc.identifier.wosWOS:000294191000002
dc.language.isoeng
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofHuman Pathology
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,304
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDeep invasive fronten
dc.subjectLaryngeal squamous cell carcinomasen
dc.subjectCortactinen
dc.subjectTMAen
dc.subjectqRT-PCRen
dc.titleCortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomasen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co-elsevier Inc
unesp.author.lattes2259986546265579
unesp.author.lattes0585723113037140
unesp.author.orcid0000-0003-1647-7842[7]
unesp.author.orcid0000-0001-5865-9308[8]
unesp.author.orcid0000-0002-0869-724X[6]
unesp.author.orcid0000-0002-0481-156X[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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