Absence of significant adverse events following thalidomide administration in bitches diagnosed with mammary gland carcinomas

Página do item simplificado
dc.contributor.authorDe Campos, C. B. [UNESP]
dc.contributor.authorLavalle, G. E.
dc.contributor.authorFialho Ligório, S.
dc.contributor.authorCamargo Nunes, F.
dc.contributor.authorCarneiro, R. A.
dc.contributor.authorAmorim, R. L. [UNESP]
dc.contributor.authorCassali, G. D.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionFundação Ezequiel Dias
dc.date.accessioned2018-12-11T17:05:22Z
dc.date.available2018-12-11T17:05:22Z
dc.date.issued2016-11-19
dc.description.abstractThe aim of the study was to evaluate the incidence of adverse events (AEs) in female dogs diagnosed with advanced clinical stage mammary gland neoplasms following treatment with thalidomide. A prospective analysis of 29 female dogs treated with a high dose (HD) of 20 mg/kg/day of thalidomide for three months followed by a low dose (LD) of 10 mg/kg/day of thalidomide for three months was performed. All patients underwent physical examination, complete blood count, serum biochemistry profile, thoracic radiographs, and abdominal ultrasound analysis before the treatment and after the HD and LD. Clinical AEs were absent in 16/29 (55.17 per cent) patients following HD. An initial 3-5 day period of somnolence was described in 4/29 (13.79 per cent), prolonged somnolence in 5/29 (17.24 per cent), a short period of somnolence lasting only a few hours in 3/29 (10.34 per cent), and difficulty to rouse was described in 5/29 (17.24 per cent) cases. Two patients (6.89 per cent) presented with prolonged somnolence that interfered with activities of daily living, resulting in anticipation of the dose reduction to the proposed LD after 15 days of the HD treatment. Following dose reduction, AE improvement was observed in all patients. Albeit remaining within the reference ranges, erythrocytes, haematocrit, total leucocyte count, neutrophils, lymphocytes, monocytes and yγ-glutamyltranspeptidase showed significant alteration associated to thalidomide treatment.en
dc.description.affiliationDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) Jaboticabal Campus
dc.description.affiliationLaboratory of Comparative Pathology Department of General Pathology Federal University of Minas Gerais (UFMG)
dc.description.affiliationDepartment of Veterinary Clinic and Surgery Veterinary School Federal University of Minas Gerais (UFMG)
dc.description.affiliationDepartment of Pharmaceutical and Biotechnological Development Fundação Ezequiel Dias
dc.description.affiliationDepartment of Veterinary Clinics College of Veterinary Medicine and Animal Science Sao Paulo State University (FMVZ/UNESP) Botucatu Campus
dc.description.affiliationDepartment of General Pathology Federal University of Minas Gerais (UFMG)
dc.description.affiliationUnespDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) Jaboticabal Campus
dc.description.affiliationUnespDepartment of Veterinary Clinics College of Veterinary Medicine and Animal Science Sao Paulo State University (FMVZ/UNESP) Botucatu Campus
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2014/01329-9
dc.description.sponsorshipIdCNPq: 302449/2013-2
dc.format.extent514
dc.identifierhttp://dx.doi.org/10.1136/vr.103764
dc.identifier.citationVeterinary Record, v. 179, n. 20, p. 514-, 2016.
dc.identifier.doi10.1136/vr.103764
dc.identifier.file2-s2.0-84984666854.pdf
dc.identifier.issn0042-4900
dc.identifier.scopus2-s2.0-84984666854
dc.identifier.urihttp://hdl.handle.net/11449/173423
dc.language.isoeng
dc.relation.ispartofVeterinary Record
dc.relation.ispartofsjr0,464
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleAbsence of significant adverse events following thalidomide administration in bitches diagnosed with mammary gland carcinomasen
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-84984666854.pdf
Tamanho:
365.69 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos - Clínica e Cirurgia Veterinária - FCAV
Artigos - Clínica Veterinária - FMVZ