Anxiety and depression symptoms disrupt resting state connectivity in patients with genetic generalized epilepsies

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dc.contributor.authorGarcia, Danielle dos Santos
dc.contributor.authorPolydoro, Marina Sconzo
dc.contributor.authorMachado Alvim, Marina Kutsodontis
dc.contributor.authorIshikawa, Akari
dc.contributor.authorVasques Moreira, Jose Carlos
dc.contributor.authorNogueira, Mateus Henrique
dc.contributor.authorZanao, Tamires Araujo
dc.contributor.authorCampos, Brunno Machado de
dc.contributor.authorGomes Garcia Betting, Luiz Eduardo [UNESP]
dc.contributor.authorCendes, Fernando
dc.contributor.authorYasuda, Clarissa L.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-04T12:36:49Z
dc.date.available2019-10-04T12:36:49Z
dc.date.issued2019-04-01
dc.description.abstractObjective To analyze the lifetime trajectories in genetic generalized epilepsies (GGEs) and investigate the impact of symptoms of anxiety and depression on resting state functional connectivity (FC). Methods Seventy-four GGE patients were classified according to the pharmacological response as seizure-free (12 patients), pharmacoresistant (PhR; 14 patients), and fluctuating (FL; 48 patients). Fifty-four subjects completed both the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), and 38 also underwent 3-T resting state functional magnetic resonance imaging. These 38 patients were subdivided into a positive group (13 patients with concurrent symptoms of depression and anxiety) and a negative group (21 asymptomatic patients and four with mild anxiety or depression symptoms). For FC analysis of resting state networks, we matched 38 healthy asymptomatic volunteers and used the UF2C toolbox running on MATLAB2017/SPM12. Results The PhR group presented shorter duration of epilepsy (P = 0.016) and follow-up (P < 0.001) compared to the FL group. The PhR group showed higher levels (median = 20) on the BAI and BDI. Myoclonic seizures were the most difficult to control, as 50% of subjects persisted with them at last appointment, compared to generalized tonic-clonic seizures and absence seizures (<40%). Patients with concurrent anxiety and depression symptoms were 7.7 times more likely to exhibit pharmacoresistant seizures, although an increase of 1 year of epilepsy duration was associated with a decrease in the odds of presenting pharmacoresistance by a factor of 0.9. Overall, FC was altered between default mode network (DMN) and visuospatial/dorsal attention. However, only the positive group displayed abnormal FC between DMN and left executive control network, and between salience and visuospatial/dorsal attention. Significance Our findings may help clinicians to have a better understanding of GGE clinical course and increase attention to the potential relationship of psychopathologies and brain connectivity.en
dc.description.affiliationUniv Estadual Campinas, Lab Neuroimaging, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Neurol, Rua Vital Brasil 251, BR-13083888 Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Med, Dept Neurol & Psychiat, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Med, Dept Neurol & Psychiat, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2016/03307-8
dc.description.sponsorshipIdFAPESP: 2015/09273-5
dc.description.sponsorshipIdFAPESP: 2013/07559-3
dc.description.sponsorshipIdCNPq: 308764/2015-3
dc.description.sponsorshipIdCNPq: 402133/2017-0
dc.format.extent679-688
dc.identifierhttp://dx.doi.org/10.1111/epi.14687
dc.identifier.citationEpilepsia. Hoboken: Wiley, v. 60, n. 4, p. 679-688, 2019.
dc.identifier.doi10.1111/epi.14687
dc.identifier.issn0013-9580
dc.identifier.urihttp://hdl.handle.net/11449/185593
dc.identifier.wosWOS:000463267500011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofEpilepsia
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdefault mode network
dc.subjectexecutive control network
dc.subjectpharmacological response
dc.subjectpsychopathologies
dc.subjectsalience network
dc.subjectseizure control
dc.titleAnxiety and depression symptoms disrupt resting state connectivity in patients with genetic generalized epilepsiesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0003-1261-8257[8]
unesp.author.orcid0000-0001-9336-9568[10]

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