Minimum infusion rate and hemodynamic effects of propofol, propofol-lidocaine and propofol-lidocaine-ketamine in dogs

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dc.contributor.authorMannarino, Rodrigo [UNESP]
dc.contributor.authorLuna, Stelio Pacca Loureiro [UNESP]
dc.contributor.authorMonteiro, Eduardo Raposo [UNESP]
dc.contributor.authorBeier, Suzane Lilian [UNESP]
dc.contributor.authorSouza, Vanessa Bastos de Castro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-07-07T12:33:47Z
dc.date.available2016-07-07T12:33:47Z
dc.date.issued2012
dc.description.abstractObjective: To evaluate the effects of a constant rateinfusion (CRI) of lidocaine alone or in combinationwith ketamine on the minimum infusion rate (MIR)of propofol in dogs and to compare the hemody-namic effects produced by propofol, propofol-lido-caine or propofol-lidocaine-ketamine anesthesia. Study design: Prospective, randomized cross-overexperimental design. Animals: Fourteen adult mixed-breed dogs weighing15.8 ± 3.5 kg. Methods: Eight dogs were anesthetized on differentoccasions to determine the MIR of propofol aloneand propofol in combination with lidocaine (loadingdose [LD] 1.5 mg kg)1, CRI 0.25 mg kg)1minute)1) or lidocaine (LD 1.5 mg kg)1, CRI 0.25 mg kg)1minute)1) and ketamine (LD 1 mg kg)1, CRI 0.1 mgkg)1minute)1). In six other dogs, the hemodynamiceffects and bispectral index (BIS) were investigated. Each animal received each treatment (propofol,propofol-lidocaine or propofol-lidocaine-ketamine) on the basis of the MIR of propofol determined inthe first set of experiments. Results: Mean ± SD MIR of propofol was 0.51 ± 0.08mg kg)1minute)1. Lidocaine-ketamine significantlydecreased the MIR of propofol to 0.31 ± 0.07 mg kg)1 minute)1(37 ± 18% reduction), although lidocainealone did not (0.42 ± 0.08 mg kg)1minute)1,18 ± 7% reduction). Hemodynamic effects weresimilar in all treatments. Compared with theconscious state, in all treatments, heart rate, cardiacindex, mean arterial blood pressure, stroke index andoxygen delivery index decreased significantly, whereas systemic vascular resistance indexincreased. Stroke index was lower in dogs treatedwith propofol-lidocaine-ketamine at 30 minutescompared with propofol alone. The BIS was lowerduring anesthesia with propofol-lidocaine-ketaminecompared to propofol alone. Conclusions and clinical relevance: Lidocaine-keta-mine, but not lidocaine alone, reduced the MIR ofpropofol in dogs. Neither lidocaine nor lidocaine incombination with ketamine attenuated cardiovas-cular depression produced by a continuous rateinfusion of propofol.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, Brasil
dc.format.extent160-173
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2011.00679.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia, v. 39, n. 2, p. 160-173, 2012.
dc.identifier.doi10.1111/j.1467-2995.2011.00679.x
dc.identifier.issn1467-2987
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.urihttp://hdl.handle.net/11449/140425
dc.language.isoeng
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAnesthesiaen
dc.subjectCardiovascular effectsen
dc.subjectConstant rate infusionen
dc.subjectDogen
dc.subjectKetamineen
dc.subjectLidocaineen
dc.subjectPropofolen
dc.subjectTotal intravenous anesthesiaen
dc.titleMinimum infusion rate and hemodynamic effects of propofol, propofol-lidocaine and propofol-lidocaine-ketamine in dogsen
dc.typeArtigo
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentCirurgia e Anestesiologia Veterináriapt

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