Genomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazil

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dc.contributor.authorSlavov, Svetoslav Nanev
dc.contributor.authorBezerra, Rafael dos Santos
dc.contributor.authorRodrigues, Evandra Strazza
dc.contributor.authorSantos, Elaine Vieira
dc.contributor.authorBorges, Joseane Serrano
dc.contributor.authorde la Roque, Débora Glenda Lima
dc.contributor.authorPatané, José Salvatore Leister
dc.contributor.authorLima, Alex Ranieri Jerônimo
dc.contributor.authorRibeiro, Gabriela
dc.contributor.authorViala, Vincent Louis
dc.contributor.authorde Lima, Loyze Paola Oliveira
dc.contributor.authorMartins, Antonio Jorge
dc.contributor.authordos Santos Barros, Claudia Renata
dc.contributor.authorMarqueze, Elaine Cristina
dc.contributor.authorBernardino, Jardelina de Souza Todão
dc.contributor.authorMoretti, Debora Botequio
dc.contributor.authorBrassaloti, Ricardo Augusto
dc.contributor.authorCassano, Raquel de Lello Rocha Campos
dc.contributor.authorMariani, Pilar Drummond Sampaio Corrêa
dc.contributor.authorKitajima, João Paulo
dc.contributor.authorSantos, Bibiana
dc.contributor.authorAssato, Patricia Akemi [UNESP]
dc.contributor.authorda Silva da Costa, Felipe Allan [UNESP]
dc.contributor.authorPoleti, Mirele Daiana
dc.contributor.authorLesbon, Jessika Cristina Chagas
dc.contributor.authorMattos, Elisangela Chicaroni
dc.contributor.authorBanho, Cecilia Artico
dc.contributor.authorSacchetto, Lívia
dc.contributor.authorMoraes, Marília Mazzi
dc.contributor.authorGrotto, Rejane Maria Tommasini [UNESP]
dc.contributor.authorSouza-Neto, Jayme A. [UNESP]
dc.contributor.authorGiovanetti, Marta
dc.contributor.authorde Alcantara, Luiz Carlos Junior
dc.contributor.authorNogueira, Maurício Lacerda
dc.contributor.authorFukumasu, Heidge
dc.contributor.authorCoutinho, Luiz Lehmann
dc.contributor.authorCalado, Rodrigo Tocantins
dc.contributor.authorNeto, Raul Machado
dc.contributor.authorCovas, Dimas Tadeu
dc.contributor.authorCoccuzzo Sampaio, Sandra
dc.contributor.authorElias, Maria Carolina
dc.contributor.authorKashima, Simone
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionButantan Institute
dc.contributor.institutionNGS Soluções Genômicas
dc.contributor.institutionMendelics Análise Genômica SA
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSão José do Rio Preto
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionRio de Janeiro
dc.date.accessioned2022-04-28T19:47:50Z
dc.date.available2022-04-28T19:47:50Z
dc.date.issued2022-01-15
dc.description.abstractThe SARS-CoV-2 alpha VOC (also known as lineage B.1.1.7) initially described in the autumn, 2020 in UK, rapidly became the dominant lineage across much of Europe. Despite multiple studies reporting molecular evidence suggestive of its circulation in Brazil, much is still unknown about its genomic diversity in the state of São Paulo, the main Brazilian economic and transportation hub. To get more insight regarding its transmission dynamics into the State we performed phylogenetic analysis on all alpha VOC strains obtained between February and August 2021 from the Sao Paulo state Network for Pandemic Alert of Emerging SARS-CoV-2 variants. The performed phylogenetic analysis showed that most of the alpha VOC genomes were interspersed with viral strains sampled from different Brazilian states and other countries suggesting that multiple independent Alpha VOC introductions from Brazil and overseas have occurred in the São Paulo State over time. Nevertheless, large monophyletic clusters were also observed especially from the Central-West part of the São Paulo State (the city of Bauru) and the metropolitan region of the São Paulo city. Our results highlight the Alpha VOC molecular epidemiology in the São Paulo state and reinforce the need for continued genomic surveillance strategies for the real-time monitoring of potential emerging SARS-CoV-2 variants during the ever-growing vaccination process.en
dc.description.affiliationUniversity of São Paulo Ribeirão Preto Medical School Blood Center of Ribeirão Preto
dc.description.affiliationButantan Institute
dc.description.affiliationUniversity of São Paulo Centro de Genômica Funcional da ESALQ
dc.description.affiliationNGS Soluções Genômicas
dc.description.affiliationMendelics Análise Genômica SA
dc.description.affiliationSão Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology
dc.description.affiliationDepartment of Veterinary Medicine School of Animal Science and Food Engineering University of Sao Paulo
dc.description.affiliationMedicine School of São José do Rio Preto (FAMERP) São José do Rio Preto
dc.description.affiliationMolecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School
dc.description.affiliationInstituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte
dc.description.affiliationInstituto Oswaldo Cruz FIOCRUZ Rio de Janeiro
dc.description.affiliationUniversity of São Paulo Ribeirão Preto Medical School
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology
dc.description.affiliationUnespMolecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFinanciadora de Estudos e Projetos
dc.description.sponsorshipIdFAPESP: 2017/26950–6
dc.description.sponsorshipIdFAPESP: 2018/15826–5
dc.description.sponsorshipIdFAPESP: 2019/08528–0
dc.description.sponsorshipIdFAPESP: 2020/10127; 2020/05367–3
dc.description.sponsorshipIdFinanciadora de Estudos e Projetos: 207.234
dc.identifierhttp://dx.doi.org/10.1016/j.virusres.2021.198643
dc.identifier.citationVirus Research, v. 308.
dc.identifier.doi10.1016/j.virusres.2021.198643
dc.identifier.issn1872-7492
dc.identifier.issn0168-1702
dc.identifier.scopus2-s2.0-85120480457
dc.identifier.urihttp://hdl.handle.net/11449/222975
dc.language.isoeng
dc.relation.ispartofVirus Research
dc.sourceScopus
dc.subjectAlpha VOC
dc.subjectB.1.1.7
dc.subjectBrazil
dc.subjectGenomic surveillance
dc.subjectSARS-CoV-2
dc.subjectSão Paulo
dc.titleGenomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazilen
dc.typeArtigo

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