Heterologous fibrin sealant derived from snake venom: From bench to bedside - an overview

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dc.contributor.authorFerreira, Rui Seabra [UNESP]
dc.contributor.authorde Barros, Luciana Curtolo [UNESP]
dc.contributor.authorAbbade, Luciana Patrícia Fernandes [UNESP]
dc.contributor.authorBarraviera, Silvia Regina Catharino Sartori [UNESP]
dc.contributor.authorSilvares, Maria Regina Cavariani [UNESP]
dc.contributor.authorde Pontes, Leticia Gomes [UNESP]
dc.contributor.authordos Santos, Lucilene Delazari [UNESP]
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:11:02Z
dc.date.available2018-12-11T17:11:02Z
dc.date.issued2017-04-04
dc.description.abstractHemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom.en
dc.description.affiliationSão Paulo State University (UNESP - Univ Estadual Paulista) Graduate Program in Tropical Diseases Botucatu Medical School
dc.description.affiliationSão Paulo State University (UNESP - Univ Estadual Paulista) Center for the Study of Venoms and Venomous Animals (CEVAP)
dc.description.affiliationSão Paulo State University (UNESP - Univ Estadual Paulista) Department of Dermatology and Radiology Botucatu Medical School
dc.description.affiliationCEVAP/UNESP, Avenida José Barbosa de Barros, 1780
dc.description.affiliationUnespSão Paulo State University (UNESP - Univ Estadual Paulista) Graduate Program in Tropical Diseases Botucatu Medical School
dc.description.affiliationUnespSão Paulo State University (UNESP - Univ Estadual Paulista) Center for the Study of Venoms and Venomous Animals (CEVAP)
dc.description.affiliationUnespSão Paulo State University (UNESP - Univ Estadual Paulista) Department of Dermatology and Radiology Botucatu Medical School
dc.description.affiliationUnespCEVAP/UNESP, Avenida José Barbosa de Barros, 1780
dc.identifierhttp://dx.doi.org/10.1186/s40409-017-0109-8
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 23, n. 1, 2017.
dc.identifier.doi10.1186/s40409-017-0109-8
dc.identifier.fileS1678-91992017000100204.pdf
dc.identifier.issn1678-9199
dc.identifier.issn1678-9180
dc.identifier.lattes8084974543029515
dc.identifier.lattes9348918548022920
dc.identifier.scieloS1678-91992017000100204
dc.identifier.scopus2-s2.0-85016943744
dc.identifier.urihttp://hdl.handle.net/11449/174422
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBuffaloes
dc.subjectCryoprecipitate coagulum
dc.subjectFibrin sealant
dc.subjectSnake venom
dc.subjectThrombin-like enzyme
dc.titleHeterologous fibrin sealant derived from snake venom: From bench to bedside - an overviewen
dc.typeResenha
unesp.advisor.lattes9348918548022920
unesp.author.lattes8084974543029515
unesp.author.lattes6840524602748457[8]
unesp.author.orcid0000-0002-9855-5594[8]

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Artigos - Doenças Tropicais e Diagnósticos por Imagem - FMB
Artigos - Dermatologia e Radioterapia - FMB
Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos