6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities

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dc.contributor.authorCuin, Alexandre
dc.contributor.authorMassabni, Antonio Carlos [UNESP]
dc.contributor.authorPereira, Guilherme Alves
dc.contributor.authorFujimura Leite, Clarice Queico [UNESP]
dc.contributor.authorPavan, Fernando Rogerio [UNESP]
dc.contributor.authorSesti-Costa, Renata
dc.contributor.authorHeinrich, Tassiele Andrea
dc.contributor.authorCosta-Neto, Claudio M.
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:15Z
dc.date.available2014-05-20T13:24:15Z
dc.date.issued2011-08-01
dc.description.abstractSynthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified H2MP aqueous solution with an equimolar aqueous solution of AgNO3 or Au(CN)2. The Au(III) complex with HMP-, AuIIIHMP, was obtained by adding an aqueous solution of K(AuCl4) to an acidified H2MP aqueous solution (1: 1 molar ratio) and the final solution was acidified with HCl to pH = 1.0. The Au(III) MP complex, KAu(MP)2, was obtained by adding an aqueous solution of K(AuCl4) to a basic H2MP solution (M: L - 1: 2 molar ratio). Formulas for the complexes are: (Ag[C5H3N4S])*H2O for AgHMP, (Au[C5H3N4S]) for AuIHMP, (Au[C5H3N4S][Cl]2)*2H2O for AuIIIHMP and K(Au[C5H2N4S]2)center dot 2H2O for KAu(MP) 2. The AuIHMP and KAu(MP) 2 complexes decreased cell viability of HeLa cancer cells in vitro. The IC50 values for AuIHMP and KAu(MP) 2 are 3.0 and 30.0 mu M, respectively. Anti-M. tuberculosis assays showed a MIC value of 2.24 mu M for AuIHMP and 5.12 mu M for free MP while AgHMP is active at the concentration 93.2 mu M. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUFJF, Inst Ciencias Exatas, Dept Quim, Juiz de Fora, MG, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, São Paulo, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Araraquara, SP, Brazil
dc.description.affiliationUSP, Fac Med, Dept Bioquim & Imunol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/58923-3
dc.description.sponsorshipIdFAPESP: 07/55851-4
dc.description.sponsorshipIdCNPq: 151.528/2004-7
dc.format.extent334-338
dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2011.04.012
dc.identifier.citationBiomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 65, n. 5, p. 334-338, 2011.
dc.identifier.doi10.1016/j.biopha.2011.04.012
dc.identifier.issn0753-3322
dc.identifier.urihttp://hdl.handle.net/11449/7467
dc.identifier.wosWOS:000296961200004
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.ispartofjcr3.457
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSilveren
dc.subjectGolden
dc.subjectMercaptopurineen
dc.subjectTuberculosisen
dc.subjectArthritisen
dc.subjectCanceren
dc.title6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activitiesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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