Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats

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dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorStein, Julia [UNESP]
dc.contributor.authorBalin, Paola da Silva [UNESP]
dc.contributor.authorSterde, Érika Tissiana [UNESP]
dc.contributor.authorBarbosa, Mariana Gazoli [UNESP]
dc.contributor.authorde Aquino, Ariana Musa [UNESP]
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Grande Dourados
dc.date.accessioned2021-06-25T10:50:57Z
dc.date.available2021-06-25T10:50:57Z
dc.date.issued2021-03-01
dc.description.abstractBenzo(a)pyrene (BaP) is an ubiquitous environmental pollutant which can lead to adverse effects on male reproduction. However, the persistence of these changes on a multigenerational scale has not been sufficiently explored. This study evaluated if peripubertal exposure to BaP in male rats can induce reproductive impairment in offspring. Male rats received BaP at environmentally relevant doses (0, 0.1, 1, or 10 μg/kg/day) orally from post-natal (PND) 23–53. On PND 90, treated males were mated with non-treated females for obtaining the next generation (F1). The paternal exposure to BaP decreased the body weight of offspring on PND 1, 13 and 22, as well as it provoked a reduction in the relative anogenital distance of the males. This exposure also brought forward the onset of puberty, evidenced by an earlier vaginal opening and first estrous in females of the lowest dose group and by a delay in the testicular descent and preputial separation ages in males. The males presented a decrease in the daily sperm production and a disrupted sperm morphology. Furthermore, the testicular histology was altered, evidenced by a reduction in the Leydig cell numbers and in the seminiferous tubules diameter, as well as a disrupted seminiferous tubules staging. The estrous cyclicity and some fertility parameters were changed in the females, as well as alterations in the ovary and uterus histology were observed. BaP compromised several reproductive parameters of the F1 generation, suggesting that peripubertal exposure to this compound provokes permanent modifications in male germ line of F0 generation.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationCollege of Health Science Federal University of Grande Dourados
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent126-136
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2021.01.011
dc.identifier.citationReproductive Toxicology, v. 100, p. 126-136.
dc.identifier.doi10.1016/j.reprotox.2021.01.011
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85100314791
dc.identifier.urihttp://hdl.handle.net/11449/207221
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.sourceScopus
dc.subjectEndocrine disruptor
dc.subjectFertility
dc.subjectOffspring
dc.subjectPaternal programming
dc.subjectPolycyclic aromatic hydrocarbons
dc.titleParental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in ratsen
dc.typeArtigo
unesp.author.orcid0000-0001-8754-4876[1]
unesp.author.orcid0000-0003-4589-2770[4]
unesp.author.orcid0000-0001-8044-9585[5]

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Botucatu - CEATOX - Centro de Assistência Toxicológica