3-D Technology Used to Accurately Understand Equine Ileocolonic Aganglionosis

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dc.contributor.authorMuniz, Eliane
dc.contributor.authorLobo Ladd, Aliny A. B.
dc.contributor.authorLobo Ladd, Fernando V.
dc.contributor.authorSilva, Andrea A. P. da
dc.contributor.authorKmit, Fernanda V.
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.authorTeixeira, Raffaella [UNESP]
dc.contributor.authorMota, Ligia S. L. S. da [UNESP]
dc.contributor.authorBelli, Carla B.
dc.contributor.authorZoppa, Andre L. V. de
dc.contributor.authorSilva, Luis C. L. C. da
dc.contributor.authorMelo, Mariana P. de
dc.contributor.authorCoppi, Antonio A.
dc.contributor.institutionUniv Paranaense
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:08:51Z
dc.date.available2014-12-03T13:08:51Z
dc.date.issued2013-01-01
dc.description.abstractIleocolonic aganglionosis (ICA) is the congenital and hereditary absence of neurons that constitute the enteric nervous system and has been described in various species including humans - Hirschsprung's disease - and horses - overo lethal white syndrome (OLWS). Hirschsprung's disease affects circa 1 in 5,000 live births. At best, this disease means an inability to absorb nutrients from food (humans). At worse, in horses, it always means death. Despite our general understanding of the functional mechanisms underlying ICA, there is a paucity of reliable quantitative information about the structure of myenteric and submucosal neurons in healthy horses and there are no studies on horses with ICA. In light of these uncertainties, we have used design-based stereology to describe the 3-D structure - total number and true size of myenteric and submucosal neurons in the ileum of ICA horses. Our study has shown that ICA affects all submucosal neurons and 99% of nnyenteric neurons. The remaining myenteric neurons (0.56%) atrophy immensely, i.e. 63.8%. We believe this study forms the basis for further research, assessing which subpopulation of myenteric neurons are affected by ileocolonic aganglionosis, and we would like to propose a new nomenclature to distinguish between a complete absence of neurons aganglionosis and a weaker form of the disease which we suggest naming 'hypoganglionosis'. Our results are a step forward in understanding this disease structurally. (C) 2013 S. Karger AG, Baselen
dc.description.affiliationUniv Paranaense, Lab Expt Neurogastroenterol, Umuarama, Brazil
dc.description.affiliationUniv Sao Paulo, Coll Vet Med & Anim Sci, Lab Stochast Stereol & Chem Anat, Dept Surg, BR-05508270 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Coll Vet Med & Anim Sci, Dept Internal Med, BR-05508270 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Coll Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Coll Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Coll Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/50168-4
dc.format.extent160-168
dc.identifierhttp://dx.doi.org/10.1159/000353218
dc.identifier.citationCells Tissues Organs. Basel: Karger, v. 198, n. 2, p. 160-168, 2013.
dc.identifier.doi10.1159/000353218
dc.identifier.issn1422-6405
dc.identifier.urihttp://hdl.handle.net/11449/111637
dc.identifier.wosWOS:000326430200007
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCells Tissues Organs
dc.relation.ispartofjcr1.275
dc.relation.ispartofsjr0,572
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIleocolonic aganglionosisen
dc.subjectOvero lethal white syndromeen
dc.subjectMyenteric plexusen
dc.subjectSubmucosal plexusen
dc.subjectHorsesen
dc.subjectStereologyen
dc.title3-D Technology Used to Accurately Understand Equine Ileocolonic Aganglionosisen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
unesp.author.lattes9643433706163946[6]
unesp.author.orcid0000-0003-4513-753X[8]
unesp.author.orcid0000-0002-1256-3893[9]
unesp.author.orcid0000-0001-6256-8089[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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