Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives

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dc.contributor.authorMoro, Isabela Jacob [UNESP]
dc.contributor.authorGondo, Gabrielle Demmany Gualberto Alexandre [UNESP]
dc.contributor.authorPierri, Elaíse Gonçalves [UNESP]
dc.contributor.authorPietro, Rosemeire Cristina Linharis Rodrigues [UNESP]
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.authorde Sousa, Damião Pergentino
dc.contributor.authordos Santos, André Gonzaga [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.date.accessioned2018-12-11T17:35:35Z
dc.date.available2018-12-11T17:35:35Z
dc.date.issued2017-01-01
dc.description.abstractConsidering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β- epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal activity (MIC and MFC) were evaluated against Candida parapsilosis, C. tropicalis, C. krusei and C. albicans and the antibacterial activity (MIC and MBC) against Escherichia coli and Staphylococcus aureus. The cytotoxicity assays were performed with human cancer cell lines HepG- 2 and SiHa and the normal strain MRC-5 through sulphorrodamine B assay. Chemoprevention was evaluated through quinone reductase assay. Our results showed no cytotoxicity on tumor and normal cell lines and no induction of the quinone reductase enzyme. C- and HC- presented activity against E. coli. All compounds presented weak antifungal activity against C. tropicalis and C. parapsilosis. EP and C+ showed moderate activity against C. krusei. Results suggest the potential use of carvones and its derivatives as antifungal agents against Candida yeasts. The absence of cytotoxicity in cell lines indicates safety in the use of these compounds.en
dc.description.affiliationLaboratory of Pharmacognosy School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.affiliationLaboratory of Biotechnology School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.affiliationLaboratory of Cell Biology School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.affiliationDepartament of Pharmaceutical Sciences Health Sciences Center UFPB – Univ Federal da Paraíba
dc.description.affiliationUnespLaboratory of Pharmacognosy School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.affiliationUnespLaboratory of Biotechnology School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.affiliationUnespLaboratory of Cell Biology School of Pharmaceutical Sciences São Paulo State University (Unesp)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.identifierhttp://dx.doi.org/10.1590/s2175-97902017000400076
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 53, n. 4, 2017.
dc.identifier.doi10.1590/s2175-97902017000400076
dc.identifier.fileS1984-82502017000400602.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.scieloS1984-82502017000400602
dc.identifier.scopus2-s2.0-85041288751
dc.identifier.urihttp://hdl.handle.net/11449/179540
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCarvone/antifungal activity
dc.subjectCarvone/antimicrobial activity
dc.subjectCarvone/chemoprevention
dc.subjectCarvone/cytotoxicity
dc.titleEvaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivativesen
dc.typeArtigo
unesp.author.lattes4000625974516852[7]
unesp.author.lattes1768025290373669[5]
unesp.author.orcid0000-0002-4920-2506[7]
unesp.author.orcid0000-0003-1740-7360[5]

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