Treatment of experimental periodontal disease by antimicrobial photodynamic therapy in nicotine-modified rats

Página do item simplificado
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorFernades, Leandro Araújo [UNESP]
dc.contributor.authorMacarini, Valmir Campos [UNESP]
dc.contributor.authorAlmeida, Juliano Milanezi de [UNESP]
dc.contributor.authorMartins, Thiago Marchi [UNESP]
dc.contributor.authorBosco, Alvaro Francisco [UNESP]
dc.contributor.authorNagata, Maria Jose Hitomi [UNESP]
dc.contributor.authorCirelli, Joni Augusto [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.contributor.institutionCentro Universitário da Fundação Educacional de Barretos (UNIFEB)
dc.date.accessioned2016-01-28T16:55:48Z
dc.date.available2016-01-28T16:55:48Z
dc.date.issued2011
dc.description.abstractBackground The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. Material & Methods A total of 240 rats were evenly divided into two groups: C – saline solution treatment; N – nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP – irrigation with saline solution; Toluidine Blue-O (TBO) – irrigation with phenothiazinium dye (100 μg/ml); LLLT – laser irradiation (660 nm; 0.03 W; 4 J); and aPDT – TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed. Results Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods. Conclusion Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, Aracatuba, Rua Jose Bonifacio 1193, Vila Mendonça, CEP 16015-050, SP, Brasil
dc.description.affiliationDepartmentof Clinic and Surgery, Federal University ofAlfenas, Alfenas, MG, Brazil;3Mastercourse, University Center of the EducationalFoundation of Barretos (UNIFEB), DentalSchool of Barretos, Barretos, SP, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, Araçatuba, Rua José Bonifacio 1193, Vila Mendonça, CEP 16015-050, SP, Brasil
dc.description.affiliationUnespDepartment of Diagnosis and Surgery,Division of Periodontics, São Paulo StateUniversity, Araraquara, São Paulo, Brazil
dc.format.extent1106-1114
dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2011.01785.x
dc.identifier.citationJournal of Clinical Periodontology, v. 38, p. 1106-1114, 2011.
dc.identifier.doi10.1111/j.1600-051X.2011.01785.x
dc.identifier.issn0303-6979
dc.identifier.lattes4774447118127346
dc.identifier.lattes4068921369233125
dc.identifier.lattes0047062193534190
dc.identifier.lattes0939609150485625
dc.identifier.lattes8399870097572073
dc.identifier.lattes2628593693450121
dc.identifier.lattes9831236034935598
dc.identifier.urihttp://hdl.handle.net/11449/133602
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofjcr4.046
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAlveolar bone lossen
dc.subjectLasersen
dc.subjectnicotineen
dc.subjectOsteoclastsen
dc.subjectPeriodontitisen
dc.subjectPhotochemotherapyen
dc.titleTreatment of experimental periodontal disease by antimicrobial photodynamic therapy in nicotine-modified ratsen
dc.typeArtigo
unesp.author.lattes4774447118127346
unesp.author.lattes4068921369233125
unesp.author.lattes0047062193534190
unesp.author.lattes0939609150485625
unesp.author.lattes8399870097572073
unesp.author.lattes2628593693450121
unesp.author.lattes9831236034935598
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

Arquivos

Coleções

Artigos - Diagnóstico e Cirurgia - FOAR