Compartment-specific expression of natural killer cell markers in renal transplantation: Immune profile in acute rejection

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dc.contributor.authorDos Santos, Daniela Cristina [UNESP]
dc.contributor.authorCampos, Erika Fernandes
dc.contributor.authorSaraiva Câmara, Niels Olsen
dc.contributor.authorDavid, Daisa Silva Ribeiro
dc.contributor.authorMalheiros, Denise Maria Avancini Costa
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:59:57Z
dc.date.available2018-12-11T16:59:57Z
dc.date.issued2016-04-01
dc.description.abstractNatural killer (NK) cells have been implicated in graft dysfunction. Here, we formulated hypothesis that distinct patterns of expression NK cells markers correlated with acute rejection in kidney transplantation. Therefore, we studied the pattern of NK cell markers CD56, CD57, and CD16 in different compartments of biopsies obtained from recipients diagnosed with acute graft rejection, with or without donor-specific antibodies (DSA). DSA-negative biopsies-from patients with acute T-cell mediated rejection (aTCMR) had an increased expression of CD56+ and CD57+ cells (P = 0.004 and P = 0.001) in the interstitial compartment in comparison with DSA-positive biopsies from patients acute antibody-mediated rejection (aABMR) with (aABMR C4d+) and without C4d deposition (aABMR C4d-). CD16+ cells was increased (P = 0.03) in the glomerular compartment in DSA-positive biopsies. We assume that CD16+ expression and antibody-dependent cellular cytotoxicity (ADCC) in microvascular injury can be associated with aABMR. IFN-γ release from cytoplasmic granules of NK cell could be associated with aTCMR. Our findings suggest that NK cells need to be carefully evaluated because variations in NK cell marker expression might imply the involvement of different immune system pathways in graft rejection.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School (FMB) State University of São Paulo (UNESP), Rubião Junior s/n
dc.description.affiliationDepartment of Pathology Faculty of Medicine University of São Paulo
dc.description.affiliationDepartment of Immunology Institute of Biomedical Sciences University of São Paulo State
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School (FMB) State University of São Paulo (UNESP), Rubião Junior s/n
dc.format.extent443-452
dc.identifierhttp://dx.doi.org/10.1111/tri.12726
dc.identifier.citationTransplant International, v. 29, n. 4, p. 443-452, 2016.
dc.identifier.doi10.1111/tri.12726
dc.identifier.issn1432-2277
dc.identifier.issn0934-0874
dc.identifier.scopus2-s2.0-84952705852
dc.identifier.urihttp://hdl.handle.net/11449/172372
dc.language.isoeng
dc.relation.ispartofTransplant International
dc.relation.ispartofsjr1,255
dc.relation.ispartofsjr1,255
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectacute antibody-mediated rejection
dc.subjectacute T-cell mediated rejection
dc.subjectdonor-specific antibodies
dc.subjectnatural killer cells
dc.subjectrenal allograft pathology
dc.titleCompartment-specific expression of natural killer cell markers in renal transplantation: Immune profile in acute rejectionen
dc.typeArtigo

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