Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats

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dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorSantos, Daniel F. B. [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorSantos, Priscila P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:15Z
dc.date.available2014-05-27T11:26:15Z
dc.date.issued2011-12-01
dc.description.abstractBackground: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.en
dc.description.affiliationFaculdade de Medicina de Botucatu, Botucatu, SP
dc.description.affiliationUnespFaculdade de Medicina de Botucatu, Botucatu, SP
dc.format.extent502-506
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2011005000117
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.
dc.identifier.doi10.1590/S0066-782X2011005000117
dc.identifier.file2-s2.0-84856358242.pdf
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.lattes1590971576309420
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.scieloS0066-782X2011005000117
dc.identifier.scopus2-s2.0-84856358242
dc.identifier.urihttp://hdl.handle.net/11449/72879
dc.language.isoeng
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEchocardiography
dc.subjectMyocardial infarction
dc.subjectRats
dc.subjectVentricular remodeling
dc.subjectacute heart infarction
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectheart ejection fraction
dc.subjectheart infarction size
dc.subjectheart ventricle remodeling
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectMale
dc.subjectMyocardial Infarction
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.subjectVentricular Dysfunction, Left
dc.subjectVentricular Remodeling
dc.titleEchocardiographic predictors of ventricular remodeling after acute myocardial infarction in ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/iaboutj.htm
unesp.author.lattes5016839015394547
unesp.author.lattes1590971576309420
unesp.author.lattes1213140801402647[2]
unesp.author.lattes7438704034471673
unesp.author.lattes4563764623232492[4]
unesp.author.orcid0000-0002-5843-6232[2]
unesp.author.orcid0000-0002-2875-9532[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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