Three-Dimensional Sonographic Assessment of Placental Volume and Vascularization in Pregnancies Complicated by Hypertensive Disorders

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dc.contributor.authorAlmeida Pimenta, Eduardo Jorge de
dc.contributor.authorSilva de Paula, Carla Fagundes
dc.contributor.authorDuarte Bonini Campos, Juliana Alvares [UNESP]
dc.contributor.authorFox, Karin Anneliese
dc.contributor.authorFrancisco, Rossana
dc.contributor.authorRuano, Rodrigo
dc.contributor.authorZugaib, Marcelo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBaylor Coll Med
dc.date.accessioned2014-12-03T13:10:50Z
dc.date.available2014-12-03T13:10:50Z
dc.date.issued2014-03-01
dc.description.abstractObjectives-The purpose of this study was to evaluate the association between placental volumes, placental vascularity, and hypertensive disorders in pregnancy.Methods A prospective case-control study was conducted between April 2011 and July 2012. Placental volumes and vascularity were evaluated by 3-dimensional sonographic, 3-dimensional power Doppler histographic, and 2-dimensional color Doppler studies. Pregnant women were classified as normotensive or hypertensive and stratified by the nature of their hypertensive disorders. The following variables were evaluated: observed-to-expected placental volume ratio, placental volume-to-estimated fetal weight ratio, placental vascular indices, and pulsatility indices of the right and left uterine and umbilical arteries.Results Sixty-six healthy pregnant women and 62 pregnant women with hypertensive disorders were evaluated (matched by maternal age, gestational age at sonography, and parity). Placental volumes were not reduced in pregnancy in women with hypertensive disorders (P > .05). Conversely, reduced placental vascularization indices (vascularization index and vascularization-flow index) were observed in pregnancies complicated by hypertensive disorders (P < .01; P < .01), especially in patients with superimposed preeclampsia (P = .04; P = .02). A weak correlation was observed between placental volumes, placental vascular indices, and Doppler studies of the uterine and umbilical arteries.Conclusions Pregnancies complicated by hypertensive disorders are associated with reduced placental vascularity but not with reduced placental volumes. These findings are independent of changes in uterine artery Doppler studies. Future studies of the prediction of preeclampsia may focus on placental vascularity in combination with results of Doppler studies of the uterine arteries.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol, Social Dept, Araraquara, Brazil
dc.description.affiliationBaylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol, Social Dept, Araraquara, Brazil
dc.format.extent483-491
dc.identifierhttp://dx.doi.org/10.7863/ultra.33.3.483
dc.identifier.citationJournal Of Ultrasound In Medicine. Laurel: Amer Inst Ultrasound Medicine, v. 33, n. 3, p. 483-491, 2014.
dc.identifier.doi10.7863/ultra.33.3.483
dc.identifier.issn0278-4297
dc.identifier.urihttp://hdl.handle.net/11449/112576
dc.identifier.wosWOS:000332137700012
dc.language.isoeng
dc.publisherAmer Inst Ultrasound Medicine
dc.relation.ispartofJournal of Ultrasound In Medicine
dc.relation.ispartofjcr1.530
dc.relation.ispartofsjr0,586
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectarterial hypertensionen
dc.subjectDoppler studyen
dc.subjectobstetric ultrasounden
dc.subjectplacental volumeen
dc.subjectplacental sizeen
dc.subjectplacental vascularityen
dc.subjectpreeclampsiaen
dc.subjectpregnancyen
dc.subject3-dimensional power Doppler sonographyen
dc.subject3-dimensional sonographyen
dc.subjectumbilical arteriesen
dc.subjectuterine arteriesen
dc.titleThree-Dimensional Sonographic Assessment of Placental Volume and Vascularization in Pregnancies Complicated by Hypertensive Disordersen
dc.typeArtigo
dcterms.rightsHolderAmer Inst Ultrasound Medicine
unesp.author.orcid0000-0002-9981-8069[5]
unesp.author.orcid0000-0002-8405-772X[4]
unesp.author.orcid0000-0003-1155-2671[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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