Effect of exercise on the reproductive outcome and fetal development of diabetic rats

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dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorKempinas, W. G. [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.date.accessioned2014-05-20T13:35:22Z
dc.date.available2014-05-20T13:35:22Z
dc.date.issued2009-12-01
dc.description.abstractThe aim of this study was to evaluate the effect of exercise on pregnancy outcome in streptozotocin-induced diabetic Wistar rats (n = 11 animals/group). These animals were randomly assigned to sedentary (G1) and exercised groups, beginning from day 0 (G2) or 7 (G3) to day 20 of pregnancy. The moderate exercise was a swimming programme. At day 21 of pregnancy, all rats were anaesthetized and killed to obtain pregnancy outcome data. All rats presented glycaemia higher than 300 mg/dl, regardless of the exercise training. The G3 group showed higher live fetus number per implantation site and lower resorption number per implantation site compared with the G I group. The fetal and placental mean weights per litter and the total number of ossification sites were significantly lower in the exercised groups (P < 0.05). Placental index was lower in the G2 and G3 groups compared with the G I group. The occurrence of skeletal anomalies indicated that exercise increased the number of altered fetuses. Thus, moderate exercise achieved better outcomes by increasing the number of live births and decreasing resorption. However, exercise increased skeletal anomalies and decreased fetal and placental weights.en
dc.description.affiliationSão Paulo State Univ Unesp, Lab Expt Res Gynecol & Obstet, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ Unesp, Dept Morphol, Inst Biosci, São Paulo, Brazil
dc.description.affiliationMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Cuiaba, Mato Grosso Sta, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Lab Expt Res Gynecol & Obstet, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Dept Morphol, Inst Biosci, São Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent852-858
dc.identifierhttp://dx.doi.org/10.1016/j.rbmo.2009.09.027
dc.identifier.citationReproductive Biomedicine Online. Cambridge: Reproductive Healthcare Ltd, v. 19, n. 6, p. 852-858, 2009.
dc.identifier.doi10.1016/j.rbmo.2009.09.027
dc.identifier.issn1472-6483
dc.identifier.lattes6758680388835078
dc.identifier.lattes0679387622604743
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12160
dc.identifier.wosWOS:000273671000015
dc.language.isoeng
dc.publisherReproductive Healthcare Ltd
dc.relation.ispartofReproductive BioMedicine Online
dc.relation.ispartofjcr2.967
dc.relation.ispartofsjr1,343
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanomaliesen
dc.subjectdiabetes mellitusen
dc.subjectexerciseen
dc.subjectpregnancy outcomeen
dc.subjectraten
dc.titleEffect of exercise on the reproductive outcome and fetal development of diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderReproductive Healthcare Ltd
unesp.author.lattes6758680388835078
unesp.author.lattes0679387622604743
unesp.author.orcid0000-0002-2112-5123[3]
unesp.author.orcid0000-0003-4761-4336[5]
unesp.author.orcid0000-0002-4753-3264[1]
unesp.author.orcid0000-0002-9227-832X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB