Lack of association between 11 gene polymorphisms on weight loss 1 year after Rous-en-y gastric bypass surgery in woman

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dc.contributor.authorNovais, Patrícia Fatima Sousa [UNESP]
dc.contributor.authorCrisp, Alex Harley
dc.contributor.authorLeandro-Merhi, Vania Aparecida
dc.contributor.authorVerlengia, Rozangela
dc.contributor.authorRasera, Irineu
dc.contributor.authorde Oliveira, Maria Rita Marques [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Metodista de Piracicaba
dc.contributor.institutionPUC-Campinas
dc.contributor.institutionClínica Bariátrica de Piracicaba
dc.date.accessioned2022-04-28T19:52:42Z
dc.date.available2022-04-28T19:52:42Z
dc.date.issued2022-01-01
dc.description.abstractBackground: Although effective, the impact of bariatric surgery on weight loss is variable, and little is known about the influence of single-nucleotide polymorphisms (SNPs). The present study investigated the association of eleven SNPs related to obesity with weight loss 1 year after Roux-Y gastric bypass (RYGB) surgery in female patients. Methods: This prospective study included 351 women with obesity. The genotypes for eleven SNPs (GHRL–rs26802; GHSR–rs572169; LEP–rs7799039; LEPR–rs1137101; 5HT2C–rs3813929; UCP2–rs659366; UCP3–rs1800849; SH2B1–rs7498665; TAS1R2–rs35874116; TAS1R2–rs9701796; FTO–rs9939609) were determined using a real-time polymerase chain reaction and TaqMan assays. Anthropometric measurements were performed before and 1 year after RYGB surgery. To evaluate the factors that influenced the proportion of weight loss 1 year after surgery, beta regression analysis was used. The models were estimated using the GLIMMIX procedure in SAS statistical software. p < 0.05 was considered statistically significant. Results: The mean ± SD percentage of total body weight loss in 1 year was 64.4 ± 5.8% and the median was 65.0%. When assessing the proportion of weight loss in 1 year after surgery, using univariate analysis (beta regression), no SNPs influenced weight loss. Furthermore, in the multiple analysis, with stepwise process of variable selection, no variable was significant to compose the multiple model. Conclusions: The 11 SNPs investigated did not influence weight loss 1 year after RYGB surgery in female patients. This result indicates that individual behaviours and other factors might better contribute to the magnitude of loss weight loss in a short period after bariatric surgery.en
dc.description.affiliationInstitute of Biosciences Universidade Estadual Paulista Júlio de Mesquita Filho, São Paulo
dc.description.affiliationHuman Performance Laboratory Universidade Metodista de Piracicaba, São Paulo
dc.description.affiliationPostgraduate Program in Health Sciences PUC-Campinas, São Paulo
dc.description.affiliationFaculty of Health Sciences Universidade Metodista de Piracicaba, São Paulo
dc.description.affiliationClínica Bariátrica de Piracicaba, São Paulo
dc.description.affiliationUnespInstitute of Biosciences Universidade Estadual Paulista Júlio de Mesquita Filho, São Paulo
dc.identifierhttp://dx.doi.org/10.1111/jhn.13000
dc.identifier.citationJournal of Human Nutrition and Dietetics.
dc.identifier.doi10.1111/jhn.13000
dc.identifier.issn1365-277X
dc.identifier.issn0952-3871
dc.identifier.scopus2-s2.0-85127223366
dc.identifier.urihttp://hdl.handle.net/11449/223723
dc.language.isoeng
dc.relation.ispartofJournal of Human Nutrition and Dietetics
dc.sourceScopus
dc.subjectbariatric surgery
dc.subjectgenetic
dc.subjectobesity
dc.subjectsingle-nucleotide polymorphism
dc.titleLack of association between 11 gene polymorphisms on weight loss 1 year after Rous-en-y gastric bypass surgery in womanen
dc.typeArtigo
unesp.author.orcid0000-0003-1620-2806[1]
unesp.author.orcid0000-0003-4683-9576[2]
unesp.author.orcid0000-0002-2623-6471[3]
unesp.author.orcid0000-0001-8626-0476[4]
unesp.author.orcid0000-0001-6300-2319[5]
unesp.author.orcid0000-0003-1226-4364[6]

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