Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates

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dc.contributor.authorMaldarine, Juliana S.
dc.contributor.authorSanches, Bruno D. A.
dc.contributor.authorSantos, Vitória A. [UNESP]
dc.contributor.authorAmaro, Gustavo M. [UNESP]
dc.contributor.authorCalmon, Marília F. [UNESP]
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorGóes, Rejane M. [UNESP]
dc.contributor.authorVilamaior, Patricia S. L. [UNESP]
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:44:30Z
dc.date.available2019-10-06T16:44:30Z
dc.date.issued2019-01-01
dc.description.abstractThe prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known that intrauterine exposure to finasteride causes changes in the male prostate even at low dosages; however, it is not known whether these dosages are capable of causing changes in the female prostate, which is present in a large number of mammalian species, including humans. In the present study, histochemistry, immunohistochemistry, immunofluorescence, serological dosages, and three-dimensional reconstruction techniques were employed to evaluate the effects of intrauterine exposure to a low dose of finasteride (100 μg.BW/d) on postnatal prostate development in male and female Mongolian gerbils. The results indicate that the gerbil female prostate also undergoes alterations following intrauterine exposure to finasteride, exhibiting a thickening of periductal smooth muscle and increased stromal proliferation. There are also intersex differences in the impact of exposure on the expression of the androgen receptor, which was increased in males, and of the estrogen-α receptor, which was decreased in the male prostate but unchanged in females. Altogether, this study indicates there are sex differences in the effects of finasteride exposure even at low dosages.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Biology São Paulo State University (UNESP) Laboratory of Microscopy and Microanalysis
dc.description.affiliationDepartment of Biology São Paulo State University (UNESP) Laboratory of Genome Studies
dc.description.affiliationUnespDepartment of Biology São Paulo State University (UNESP) Laboratory of Microscopy and Microanalysis
dc.description.affiliationUnespDepartment of Biology São Paulo State University (UNESP) Laboratory of Genome Studies
dc.identifierhttp://dx.doi.org/10.1002/tox.22838
dc.identifier.citationEnvironmental Toxicology.
dc.identifier.doi10.1002/tox.22838
dc.identifier.issn1522-7278
dc.identifier.issn1520-4081
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.scopus2-s2.0-85071230707
dc.identifier.urihttp://hdl.handle.net/11449/189557
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectandrogen receptor
dc.subjectestrogen receptor
dc.subjectfemale prostate
dc.subjectfinasteride
dc.subjectgerbil
dc.subjectintrauterine exposure
dc.subjectlow-dose exposure
dc.subjectsmooth muscle
dc.titleLow-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostatesen
dc.typeArtigo
unesp.author.lattes7991082362671212[6]
unesp.author.orcid0000-0002-0970-4288[9]
unesp.author.orcid0000-0001-5693-6148[6]

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