Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing

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dc.contributor.authorKinkead, Richard
dc.contributor.authorTenorio, Luana [UNESP]
dc.contributor.authorDrolet, Guy
dc.contributor.authorBretzner, Frederic
dc.contributor.authorGargaglioni, Luciane
dc.contributor.institutionCtr Hosp Univ Quebec
dc.contributor.institutionUniv Laval
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:54:02Z
dc.date.available2015-03-18T15:54:02Z
dc.date.issued2014-12-01
dc.description.abstractThe control of breathing is commonly viewed as being a "brainstem affair". As the topic of this special issue of Respiratory Physiology and Neurobiology indicates, we should consider broadening this notion since the act of breathing is also tightly linked to many functions other than close regulation of arterial blood gases. Accordingly, "non-brainstem" structures can exert a powerful influence on the core elements of the respiratory control network and as it is often the case, the importance of these structures is revealed when their dysfunction leads to disease. There is a clear link between respiration and anxiety and key theories of the psychopathology of anxiety (including panic disorders; PD) focus on respiratory control and related CO2 monitoring system. With that in mind, we briefly present the respiratory manifestations of panic disorder and discuss the role of the dorso-medial/perifornical hypothalamus, the amygdalar complex, and the periaqueductal gray in respiratory control. We then present recent advances in basic research indicating how adult rodent previously subjected to neonatal stress may provide a very good model to investigate the pathophysiology of PD. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationCtr Hosp Univ Quebec, Ctr Rech, Quebec City, PQ, Canada
dc.description.affiliationUniv Laval, Quebec City, PQ G1L 3L5, Canada
dc.description.affiliationUNESP FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUNESP FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent3-13
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2014.06.013
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 204, p. 3-13, 2014.
dc.identifier.doi10.1016/j.resp.2014.06.013
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11449/116733
dc.identifier.wosWOS:000346457900002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectControl of breathingen
dc.subjectPanic disorderen
dc.subjectChemoreflexen
dc.subjectHypercapnic responseen
dc.titleRespiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathingen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-9686-2577[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV