Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration

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dc.contributor.authorZanatelli, Marianna
dc.contributor.authorColleta, Simone Jacovaci [UNESP]
dc.contributor.authorGuerra, Luiz Henrique Alves [UNESP]
dc.contributor.authorSantos, Fernanda Cristina Alcântara
dc.contributor.authorGóes, Rejane Maira [UNESP]
dc.contributor.authorVilamaior, Patricia Simone Leite [UNESP]
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2022-04-29T08:30:15Z
dc.date.available2022-04-29T08:30:15Z
dc.date.issued2021-12-01
dc.description.abstractBackground: The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. The aim of the present study was to evaluate the effects of exposure to exogenous prolactin in the prostate of both intact and castrated male and female gerbils in order to establish if prolactin administration can sustain prostate cell activity in conditions of sexual hormone deprivation. Methods: The morphological analyses were performed by biometric analysis, lesion histological analysis and morphometric-stereological aspects. In addition, immune-cytochemical tests were performed for prolactin and its receptor, as well as for the receptors of androgen and oestrogen and serum prolactin dosage. All data were submitted to ANOVA or Kruskal-Wallis tests for comparison between groups. P < 0.05 was considered to be statistically significant. Results: The results showed a strong influence of prolactin on the morphology of the prostate, with the development of important epithelial alterations, after only 3 days of administration, and an expressive epithelial cell discard process after 30 days of administration. Prolactin acts in synergy with testosterone in males and mainly with oestrogens in females, establishing different steroid hormonal receptor immunoreactivity according to sex. It was also demonstrated that prolactin can assist in the recovery from some atrophic effects caused in the gland after castration, without causing additional tissue damage. Conclusions: The prolactin and its receptor are involved in the maintenance of the homeostasis of male and female gerbils, and also cause distinct histological alterations after exogenous exposure for 3 and 30 days. The effects of prolactin are related to its joint action on androgens and oestrogens and it can also assist in the recovery from the atrophic effects of castration.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology State University of Campinas – UNICAMP
dc.description.affiliationLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University – UNESP/IBILCE, Rua Cristóvão Colombo, 2265, Jardim Nazareth
dc.description.affiliationDepartment of Morphology Federal University of Goiás -UFG
dc.description.affiliationUnespLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University – UNESP/IBILCE, Rua Cristóvão Colombo, 2265, Jardim Nazareth
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2012/00695-6
dc.description.sponsorshipIdCNPq: 301596/2011-5
dc.description.sponsorshipIdCNPq: 442630/2014-0
dc.identifierhttp://dx.doi.org/10.1186/s12958-021-00777-2
dc.identifier.citationReproductive Biology and Endocrinology, v. 19, n. 1, 2021.
dc.identifier.doi10.1186/s12958-021-00777-2
dc.identifier.issn1477-7827
dc.identifier.scopus2-s2.0-85109056782
dc.identifier.urihttp://hdl.handle.net/11449/229073
dc.language.isoeng
dc.relation.ispartofReproductive Biology and Endocrinology
dc.sourceScopus
dc.subjectCastration
dc.subjectFemale prostate
dc.subjectGerbil
dc.subjectProlactin
dc.subjectProlactin receptor
dc.subjectProstate
dc.titleProlactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castrationen
dc.typeArtigo
unesp.author.orcid0000-0002-0970-4288[7]

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