The Burden of Genetic and Epigenetic Traits in Prematurity

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dc.contributor.authorRibeiro de Andrade Ramos, Bruna [UNESP]
dc.contributor.authorda Silva, Márcia Guimarães [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:18:44Z
dc.date.available2018-12-11T17:18:44Z
dc.date.issued2018-04-01
dc.description.abstractDespite decades of investigations and accumulated scientific knowledge, preterm birth (PTB) remains a significant burden worldwide. Several mechanisms have been proposed to explain this condition, and a number of risk factors from infectious to behavioral and genetic/epigenetic factors influence this outcome. The heritability of PTB is estimated to be 17% to 36%, which demonstrates that genetic predisposition plays a key role in PTB. Structural DNA modifications without changes in the DNA sequence and post-transcriptional regulation also have an impact on gene expression and thus influence pregnancy outcomes. There is a complex interplay between environmental factors and the individual’s genetics and epigenetics that may culminate in PTB, but the complete regulatory pathways and networks involved in this context are still unclear. Here, we outline what is known so far about the genetic and epigenetic factors involved in preterm delivery, including polymorphisms, DNA methylation, and microRNAs, and suggest fields for research.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School São Paulo State University—UNESP
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School São Paulo State University—UNESP
dc.format.extent471-479
dc.identifierhttp://dx.doi.org/10.1177/1933719117718270
dc.identifier.citationReproductive Sciences, v. 25, n. 4, p. 471-479, 2018.
dc.identifier.doi10.1177/1933719117718270
dc.identifier.file2-s2.0-85044322221.pdf
dc.identifier.issn1933-7205
dc.identifier.issn1933-7191
dc.identifier.scopus2-s2.0-85044322221
dc.identifier.urihttp://hdl.handle.net/11449/176056
dc.language.isoeng
dc.relation.ispartofReproductive Sciences
dc.relation.ispartofsjr1,001
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDNA methylation
dc.subjectepigenetics
dc.subjectgenetics
dc.subjectmicroRNA
dc.subjectpolymorphisms
dc.subjectprematurity
dc.subjectpreterm birth
dc.titleThe Burden of Genetic and Epigenetic Traits in Prematurityen
dc.typeResenha

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