Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats

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dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorJúnior, Armando Jorge
dc.contributor.authorStein, Julia [UNESP]
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorMoreira, Suyane da Silva [UNESP]
dc.contributor.authorManoel, Beatriz de Matos
dc.contributor.authorMota, Jonas da Silva
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversidade Estadual de Mato Grosso do Sul (UEMS)
dc.date.accessioned2022-04-29T08:40:17Z
dc.date.available2022-04-29T08:40:17Z
dc.date.issued2022-02-01
dc.description.abstractBackground: Piper vicosanum (Piperaceae) is a species used in folk medicine mainly due to its anti-inflammatory and analgesic properties. However, the data available about its safety are still insufficient. Purpose: This study evaluated the toxicological profile and reproductive impacts in male rats treated with the ethanolic extract from Piper vicosanum leaves (EEPV) during a 28-day treatment. Methods: Male Wistar rats received ethanol extract of EEPV (0, 100, 200, or 300 mg/kg) by gavage for 28 consecutive days. Results: Males treated with EEPV did not exhibit clinical signs of toxicity during the treatment. Although hematological parameters were unaltered, a decrease in AST, total proteins, alkaline phosphatase and creatinine levels was observed in the treated animals. However, no evidence of histological changes was found in the liver and kidney. EEPV also induced an increase of abnormal sperm in males. Conclusion: The prolonged use of ethanolic extract of Piper vicosanum leaves affected biochemical and sperm parameters, showing that care should be taken when it is used for prolonged periods. Further studies, including a 90-day toxicity assay, should be performed.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationCollege of Health Science Federal University of Grande Dourados, Mato Grosso do Sul
dc.description.affiliationMato Grosso do Sul State University UEMS, Mato Grosso do Sul State
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1016/j.phyplu.2021.100165
dc.identifier.citationPhytomedicine Plus, v. 2, n. 1, 2022.
dc.identifier.doi10.1016/j.phyplu.2021.100165
dc.identifier.issn2667-0313
dc.identifier.scopus2-s2.0-85125604803
dc.identifier.urihttp://hdl.handle.net/11449/230491
dc.language.isoeng
dc.relation.ispartofPhytomedicine Plus
dc.sourceScopus
dc.subjectBiochemical parameters
dc.subjectMale rats
dc.subjectPiper
dc.subjectReproductive toxicity
dc.subjectSafety evaluation
dc.subjectSperm morphology
dc.titleSafety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male ratsen
dc.typeArtigo

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Botucatu - CEATOX - Centro de Assistência Toxicológica