The influence of diabetes mellitus and insulin therapy on biomechanical retention around dental implants: a study in rabbits.

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dc.contributor.authorMargonar, Rogério
dc.contributor.authorSakakura, Celso E
dc.contributor.authorHolzhausen, Marinella
dc.contributor.authorPepato, Maria Teresa
dc.contributor.authorAlba, júnior Rodolfo Cândia
dc.contributor.authorMarcantonio, júnior Elcio
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:58Z
dc.date.available2014-05-27T11:20:58Z
dc.date.issued2003-12-01
dc.description.abstractThe oral rehabilitation by dental implants in patients with diabetes remains a controversial issue. The aim of this study was to evaluate the influence of diabetes mellitus and insulin therapy on the bone healing around dental implants using torque removal. Twenty-seven rabbits were randomly divided into 3 groups with 9 animals each: control (C) group, induced diabetic (D) group, and insulin-treated diabetic (ITD) group (10 U/day). After 1 week, one implant was inserted at the tibial metaphysis of the animals. The glucose levels were periodically evaluated through the glucose-oxidase enzymatic method. The animals were killed at 4, 8, and 12 weeks after surgery and the biomechanical test was performed using a torque manometer. Statistically significant differences regarding the removal torque of the implant could not be found at 4 weeks (P = 0.2) among groups. Group C showed statistically higher values than groups D and ITD at the experimental periods of 8 (P = 0.0001 and P = 0.0002, respectively) and 12 weeks (P = 0.0053 and P = 0.001, respectively). There were no statistical differences between D and ITD groups in any of the experimental periods. Diabetes mellitus has negatively influenced the mechanical retention of implants placed at the tibial metaphysis of rabbits. Therapy with insulin did not induce any changes.en
dc.format.extent333-339
dc.identifierhttp://journals.lww.com/implantdent/Abstract/2003/12040/The_Influence_of_Diabetes_Mellitus_and_Insulin.14.aspx
dc.identifier.citationImplant dentistry, v. 12, n. 4, p. 333-339, 2003.
dc.identifier.issn1056-6163
dc.identifier.scopus2-s2.0-1442339381
dc.identifier.urihttp://hdl.handle.net/11449/67527
dc.language.isoeng
dc.relation.ispartofImplant Dentistry
dc.relation.ispartofjcr1.307
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectinsulin
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectbiomechanics
dc.subjectbone regeneration
dc.subjectdevice removal
dc.subjectexperimental diabetes mellitus
dc.subjectfemale
dc.subjectimplant
dc.subjectnonparametric test
dc.subjectpathophysiology
dc.subjectrabbit
dc.subjecttibia
dc.subjecttime
dc.subjecttooth implantation
dc.subjecttorque
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBiomechanics
dc.subjectDental Implantation, Endosseous
dc.subjectDental Implants
dc.subjectDevice Removal
dc.subjectDiabetes Mellitus, Experimental
dc.subjectFemale
dc.subjectImplants, Experimental
dc.subjectInsulin
dc.subjectOsseointegration
dc.subjectRabbits
dc.subjectStatistics, Nonparametric
dc.subjectTibia
dc.subjectTime Factors
dc.subjectTorque
dc.titleThe influence of diabetes mellitus and insulin therapy on biomechanical retention around dental implants: a study in rabbits.en
dc.typeArtigo
unesp.author.orcid0000-0002-9660-4524[6]

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