Global gene expression profile in myelodysplastic syndromes using SAGE

Página do item simplificado
dc.contributor.authorMendiburu, C. F. [UNESP]
dc.contributor.authorSilva, W. A.
dc.contributor.authorRicci, O.
dc.contributor.authorBonini-Domingos, C. R. [UNESP]
dc.contributor.authorFett-Conte, A. C.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto
dc.date.accessioned2022-04-28T20:46:17Z
dc.date.available2022-04-28T20:46:17Z
dc.date.issued2008-12-01
dc.description.abstractThe molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a partial transcriptome of RAEB bone marrow derived from 56,694 sequenced tags that provides information about expressed gene products. This is the first attempt to determine an overall profile of gene expression specifically in RAEB at diagnosis using SAGE, which should be useful in the understanding of the physiopathology of MDS and in identifying the genes involved. ©FUNPEC-RP.en
dc.description.affiliationDepartamento de Biologia Instituto de Biociência Letras e Ciências Exatas Universidade Estadual de São Paulo, São José do Rio Preto, SP
dc.description.affiliationDepartamento de Genética Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SP
dc.description.affiliationDepartamento de Medicina Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP
dc.description.affiliationDepartamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP
dc.description.affiliationUnespDepartamento de Biologia Instituto de Biociência Letras e Ciências Exatas Universidade Estadual de São Paulo, São José do Rio Preto, SP
dc.format.extent1245-1250
dc.identifierhttp://dx.doi.org/10.4238/vol7-4gmr521
dc.identifier.citationGenetics and Molecular Research, v. 7, n. 4, p. 1245-1250, 2008.
dc.identifier.doi10.4238/vol7-4gmr521
dc.identifier.issn1676-5680
dc.identifier.scopus2-s2.0-56749169148
dc.identifier.urihttp://hdl.handle.net/11449/225345
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Research
dc.sourceScopus
dc.subjectGene expression profile
dc.subjectMyelodysplastic syndrome
dc.subjectRefractory anemia with excess blasts
dc.subjectSerial analysis of gene expression methodology
dc.titleGlobal gene expression profile in myelodysplastic syndromes using SAGEen
dc.typeArtigo

Arquivos

Coleções

Artigos - Biologia - IBILCE