Genome-wide associations and detection of candidate genes for direct and maternal genetic effects influencing growth traits in the Montana Tropical (R) Composite population

Página do item simplificado
dc.contributor.authorGrigoletto, Lais
dc.contributor.authorBrito, Luiz Fernando
dc.contributor.authorMattos, Elisangela C.
dc.contributor.authorEler, Joanir Pereira
dc.contributor.authorBussiman, Fernando Oliveira
dc.contributor.authorAbreu Silva, Barbara da Conceicao
dc.contributor.authorSilva, Rosiane Pereira da
dc.contributor.authorCarvalho, Felipe Eguti
dc.contributor.authorBerton, Mariana Piatto [UNESP]
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.authorSterman Ferraz, Jose Bento
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPurdue Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T17:02:25Z
dc.date.available2020-12-10T17:02:25Z
dc.date.issued2019-11-01
dc.description.abstractThe Montana Tropical (R) Composite beef cattle have been developed in Brazil to serve as a genetic resource to meet the consumers' needs for higher-quality meat while animals are raised in extensive production systems under tropical conditions. In order to optimize the selection process for economically important traits in this population, various genetic and genomic studies are still lacking. In this regard, the aim of this study was to assess genetic parameters and identify genomic regions and potential candidate genes associated with various growth traits, using the single-step Genomic Best Linear Unbiased Predictor (ssGBLUP) method. Approximately 400,000 cows, bulls and progeny had measurements for birth weight (BW), weaning weight (WW), yearling weight (YW) and post-weaning weight gain (WG). A total of 1394 animals were genotyped for 27,199 SNPs (after the quality control) to enable implementation of weighted single-step genome-wide association studies. The traits included in this study were shown to be moderately heritable (i.e. heritability estimates ranging from 0.16 +/- 0.01 to 0.33 +/- 0.04) and the genetic correlations ranged from 0.60 +/- 0.067 (between WW and WG) to 0.88 +/- 0.08 (between BW and WW). Single-trait weighted genome-wide association studies enabled the identification of 83 genomic regions for direct genetic effects (all traits) and 29 genomic regions associated with maternal genetic effects on BW and WW traits. Furthermore, biological processes and pathways associated with survival to adult age, calf behavior, fatty acid metabolism, muscle development, fertility, and immune system were identified. The findings of this study greatly contribute to a better understanding of the genetic architecture of growth traits in the Montana Tropical (R) Composite population. Furthermore, the genomic regions identified can be given more importance (weight) when implementing genomic selection for these traits, by using weighted ssGBLUP or Bayesian approaches.en
dc.description.affiliationUniv Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Vet Med, Ave Duque de Caxias Norte 225, BR-13635900 Pirassununga, SP, Brazil
dc.description.affiliationPurdue Univ, Dept Anim Sci, W Lafayette, IN 47907 USA
dc.description.affiliationSao Paulo State Univ, Fac Ciencias Agr & Vet, Dept Anim Sci, Jaboticabal, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Fac Ciencias Agr & Vet, Dept Anim Sci, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/07566-2
dc.description.sponsorshipIdFAPESP: 2017/11919-6
dc.description.sponsorshipIdFAPESP: 2018/20393-0
dc.format.extent64-76
dc.identifierhttp://dx.doi.org/10.1016/j.livsci.2019.09.013
dc.identifier.citationLivestock Science. Amsterdam: Elsevier, v. 229, p. 64-76, 2019.
dc.identifier.doi10.1016/j.livsci.2019.09.013
dc.identifier.issn1871-1413
dc.identifier.urihttp://hdl.handle.net/11449/195032
dc.identifier.wosWOS:000501657100010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLivestock Science
dc.sourceWeb of Science
dc.subjectBiological pathways
dc.subjectComposite
dc.subjectCrossbreeding
dc.subjectGrowth
dc.subjectGenome-wide association
dc.subjectTropical beef cattle
dc.titleGenome-wide associations and detection of candidate genes for direct and maternal genetic effects influencing growth traits in the Montana Tropical (R) Composite populationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-4094-2011[10]

Arquivos

Coleções

Artigos