Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy

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dc.contributor.authorCordeiro, Renato Simões
dc.contributor.authorScarano, Wellerson Rodrigo
dc.contributor.authorGóes, Rejane Maira [UNESP]
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:01:30Z
dc.date.available2022-04-28T20:01:30Z
dc.date.issued2004-06-07
dc.description.abstractThe flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed an increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed. as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In conclusion, the flutamide treatment exerts tissue effects on the lateral prostate, promoting stroma/epithelium alterations.en
dc.description.affiliationDepartment of Cell Biology Institute of Biology UNICAMP, CP 6109, 13084-971, Campinas, SP
dc.description.affiliationLab. of Microscopy and Microanalysis Department of Biology IBILCE/UNESP, 15054-000, Sao Jose do Rio Preto, SP
dc.description.affiliationDepartamento de Biologia IBILCE/UNESP, Rua Cristovao Colombo, 2265, Sao Jose do Rio Preto, SP
dc.description.affiliationUnespLab. of Microscopy and Microanalysis Department of Biology IBILCE/UNESP, 15054-000, Sao Jose do Rio Preto, SP
dc.description.affiliationUnespDepartamento de Biologia IBILCE/UNESP, Rua Cristovao Colombo, 2265, Sao Jose do Rio Preto, SP
dc.format.extent21-30
dc.identifier.citationBiocell, v. 28, n. 1, p. 21-30, 2004.
dc.identifier.issn0327-9545
dc.identifier.scopus2-s2.0-2542458436
dc.identifier.urihttp://hdl.handle.net/11449/224602
dc.language.isoeng
dc.relation.ispartofBiocell
dc.sourceScopus
dc.subjectFlutamide, antiandrogen, secretory cells
dc.subjectLateral prostate
dc.titleTissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapyen
dc.typeArtigo

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Botucatu - CME - Centro de Microscopia Eletrônica
Artigos - Biologia - IBILCE