Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation

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dc.contributor.authorFrascino, Alexandre Viana
dc.contributor.authorCosta, Claudio
dc.contributor.authorSalgado, Daniela Miranda Richarte de Andrade
dc.contributor.authorCoracin, Fabio Luiz
dc.contributor.authorFava, Marcelo [UNESP]
dc.contributor.authorOdone-Filho, Vicente
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Nove de Julho
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:46:30Z
dc.date.available2019-10-06T15:46:30Z
dc.date.issued2019-01-01
dc.description.abstractOBJECTIVE: Hematopoietic stem-cell transplantation (HSCT) childhood survivors of hematologic malignancies are prone to develop late osteopenia and osteoporosis. The purpose of this retrospective study was to quantitatively and qualitatively assess bone mineral density (BMD) in HSCT childhood survivors and to compare the effectiveness of both qualitative and quantitative assessment methods. METHODS: DESIGN BMD assessment using panoramic radiographs of childhood HSCT survivors aged 3.69-18.88 years using two radiomorphometric indexes. Case-control double-blinded comparison of panoramic radiographic images from childhood HSCT survivors and age- and sex-matched healthy controls. Quantitative assessment was performed by measuring the cortical bone width bilaterally at the mental foramen level. Qualitative assessment was performed using the mandibular cortical index bilaterally on all panoramic images. RESULTS: Radiographs were taken 6.59-83.95 months after bone marrow transplantation [median±SD=25.92 ±24.9 months]. Fifty-two panoramic radiographic images were analyzed: 21 from HSCT survivors and 31 from healthy controls aged 3.69-25.1 years [mean±SD=11.89±5.28 years]. The mandibular cortical bone width was 17% smaller in childhood HSCT survivors than in healthy controls (case group: 2.420, control group: 3.307; p=0.00617). Qualitative analysis revealed an increased frequency of severe mandibular cortical erosion in childhood HSCT survivors, although no significant difference was observed (case group: 1.540, control group: 1.490; p=0.32). The interobserver agreement was 85% (Kappa index). CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis.en
dc.description.affiliationDepartamento de Pediatria Faculdade de Medicina FMUSP Universidade de Sao Paulo
dc.description.affiliationDepartamento de Estomatologia Faculdade de Odontologia Universidade de Sao Paulo
dc.description.affiliationDepartamento de Saude Faculdade de Odontologia Universidade Nove de Julho
dc.description.affiliationFaculdade de Odontologia Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespFaculdade de Odontologia Universidade Estadual Paulista (UNESP)
dc.identifierhttp://dx.doi.org/10.6061/clinics/2019/e929
dc.identifier.citationClinics, v. 74.
dc.identifier.doi10.6061/clinics/2019/e929
dc.identifier.fileS1807-59322019000100231.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322019000100231
dc.identifier.scopus2-s2.0-85067442051
dc.identifier.urihttp://hdl.handle.net/11449/187764
dc.language.isoeng
dc.relation.ispartofClinics
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBone Marrow Transplantation
dc.subjectChildren
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectOsteoporosis
dc.subjectRadiomorphometric Assessment
dc.titleMandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantationen
dc.typeArtigo
unesp.author.orcid0000-0002-2741-5201[1]
unesp.author.orcid0000-0003-2831-8670[2]
unesp.author.orcid0000-0003-4646-7389[3]
unesp.author.orcid0000-0002-0108-6593[4]
unesp.author.orcid0000-0003-4221-0551[6]

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