Zuspan's Scheme Versus an Alternative Magnesium Sulfate Scheme: Randomized Clinical Trial of Magnesium Serum Concentrations

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dc.contributor.authorAbbade, Joelcio Francisco [UNESP]
dc.contributor.authorCosta, Roberto Antonio de Araújo [UNESP]
dc.contributor.authorMartins, Anice M. V. C.
dc.contributor.authorBorges, Vera Therezinha Medeiros [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorPeracoil, Jose C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:26Z
dc.date.available2014-05-20T13:35:26Z
dc.date.issued2010-01-01
dc.description.abstractObjective. The purpose of this study was to determine whether magnesium serum concentrations in patients with severe preeclampsia or eclampsia treated with two different magnesium sulfate schemes were different. Methods. Fourteen patients were randomly assigned in the alternative scheme group and 15 in the Zuspan's group. The difference between the groups was that the intravenously administered maintenance dose was done with 1 g/h by continuous intravenous infusion in the Zuspan's group and 2g in bolus every two hours in the alternative scheme. Blood samples were collected previously to treatment and every 15 minutes during four hours after the beginning of treatment. The primary outcome measure was area under the curve and the t-test was used for statistical analysis with level of statistical significance of 5%. The evaluation of the punctual means at all moments in the alternative group was done with the repeated measures analysis of variance. Results. There was no significant difference in the baseline characteristics between groups. In both schemes, magnesium serum concentration reaches a peak within 15 minutes and a new peak was observed after maintenance dose in the alternative scheme. The area under the curve was significantly lower in the alternative scheme than in the Zuspan's scheme (702.1 +/- 73.5 mg/dL vs 796.1 +/- 94.6 mg/dL). Conclusion. The serum magnesium concentration of this randomized clinical trial doesn't support the use of the alternative scheme of magnesium sulfate to prevent or treat eclampsia.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Obstet & Ginecol, Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Obstet & Ginecol, Botucatu Med Sch, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 02/09590-0
dc.format.extent82-92
dc.identifierhttp://dx.doi.org/10.3109/10641950902928704
dc.identifier.citationHypertension In Pregnancy. Philadelphia: Taylor & Francis Inc, v. 29, n. 1, p. 82-92, 2010.
dc.identifier.doi10.3109/10641950902928704
dc.identifier.issn1064-1955
dc.identifier.lattes6758680388835078
dc.identifier.lattes1884059321499759
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.orcid0000-0003-4074-252X
dc.identifier.urihttp://hdl.handle.net/11449/12190
dc.identifier.wosWOS:000275369600007
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofHypertension in Pregnancy
dc.relation.ispartofjcr1.257
dc.relation.ispartofsjr0,556
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRandomized clinical trialen
dc.subjectMagnesium serum concentrationen
dc.subjectMagnesium sulfateen
dc.subjectPreeclampsiaen
dc.subjectEclampsiaen
dc.titleZuspan's Scheme Versus an Alternative Magnesium Sulfate Scheme: Randomized Clinical Trial of Magnesium Serum Concentrationsen
dc.typeResumo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes6758680388835078
unesp.author.lattes1884059321499759[2]
unesp.author.orcid0000-0002-9227-832X[5]
unesp.author.orcid0000-0003-4074-252X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB