Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients

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dc.contributor.authorDos Reis, Mariana Bisarro
dc.contributor.authorLosi-Guembarovski, Roberta
dc.contributor.authorDe Souza Fonseca Ribeiro, Enilze Maria
dc.contributor.authorCavalli, Iglenir João
dc.contributor.authorMorita, Maria Celeste
dc.contributor.authorRamos, Gyl Henrique Albrecht
dc.contributor.authorDe Oliveira, Benedito Valdecir
dc.contributor.authorMizuno, Lauro Toyoshi
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorDe Syllos Cólus, Ilce Mara
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionServiço de Cabeça e Pescoço
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:20Z
dc.date.available2014-05-27T11:28:20Z
dc.date.issued2013-02-01
dc.description.abstractBackground: The capacity for DNA repair is essential in maintaining cellular functions and homeostasis; however, this capacity can be altered based on DNA sequence variations in DNA repair genes, which may contribute to the onset of cancer. Many single-nucleotide polymorphisms (SNPs) in repair genes have been found to be associated with oral cancer. The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer. We also attempted to correlate the frequencies obtained for each of the SNPs to histopathological parameters. Methods: A case-control study was conducted with genomic DNA from 150 patients with oral squamous cell carcinomas and 150 controls. SNPs were genotyped by RFLP-PCR. Results: The presence of the polymorphic variants of the XRCC1 gene within codon 194 (OR 0.82, 95% CI: 0.44-1.51) and codon 399 (OR 0.94, 95% CI: 0.59-1.50) and within the XRCC3 gene (OR 0.72; 95% CI: 0.45-1.16) were not associated with an increased risk of oral cancer. A combinational analysis of SNPs in both genes indicated no association. The presence of the allelic variants of these two genes had no statistically significant effect on tumor differentiation, lymph node invasion or tumor size. Conclusions: These results suggest that allelic variants of XRCC1 and XRCC3 are not suitable markers for susceptibility to carcinomas of the oral cavity and are also not related to the later stages of such tumors. © 2012 John Wiley & Sons A/S.en
dc.description.affiliationDepartamento de Biologia Geral Universidade Estadual de Londrina, Londrina, PR
dc.description.affiliationDepartamento de Genética Universidade Federal do Paraná, Curitiba, PR
dc.description.affiliationDepartamento de Medicina Oral e Odontologia Infantil Universidade Estadual de Londrina, Londrina, PR
dc.description.affiliationHospital Erasto Gaertner Serviço de Cabeça e Pescoço, Curitiba, PR
dc.description.affiliationCentro Odontológico Norte do Paraná Universidade Estadual de Londrina, Londrina, PR
dc.description.affiliationDepartamento de Urologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP
dc.description.affiliationUnespDepartamento de Urologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP
dc.format.extent180-185
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0714.2012.01192.x
dc.identifier.citationJournal of Oral Pathology and Medicine, v. 42, n. 2, p. 180-185, 2013.
dc.identifier.doi10.1111/j.1600-0714.2012.01192.x
dc.identifier.issn0904-2512
dc.identifier.issn1600-0714
dc.identifier.lattes2259986546265579
dc.identifier.scopus2-s2.0-84873242692
dc.identifier.urihttp://hdl.handle.net/11449/74510
dc.identifier.wosWOS:000314471200010
dc.language.isoeng
dc.relation.ispartofJournal of Oral Pathology and Medicine
dc.relation.ispartofjcr2.237
dc.relation.ispartofsjr0,791
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectHistopathological parameters
dc.subjectOral cancer
dc.subjectPolymorphisms
dc.subjectXRCC1
dc.subjectXRCC3
dc.subjectgenomic DNA
dc.subjectadult
dc.subjectaged
dc.subjectallele
dc.subjectcancer invasion
dc.subjectcancer risk
dc.subjectcancer susceptibility
dc.subjectcodon
dc.subjectcontrolled study
dc.subjectDNA repair
dc.subjectfemale
dc.subjectgene
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmouth squamous cell carcinoma
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectrestriction fragment length polymorphism
dc.subjectsingle nucleotide polymorphism
dc.subjecttumor differentiation
dc.subjecttumor volume
dc.subjectXRCC1 gene
dc.subjectXRCC3 gene
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlleles
dc.subjectArginine
dc.subjectCarcinoma, Squamous Cell
dc.subjectCase-Control Studies
dc.subjectCodon
dc.subjectDNA Repair
dc.subjectDNA-Binding Proteins
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectGlutamine
dc.subjectHumans
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMethionine
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectPolymorphism, Genetic
dc.subjectPolymorphism, Single Nucleotide
dc.subjectRisk Factors
dc.subjectThreonine
dc.subjectTryptophan
dc.subjectYoung Adult
dc.titleAllelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patientsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes2259986546265579
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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