Global gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsites

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dc.contributor.authorSeverino, Patricia
dc.contributor.authorAlvares, Adriana M.
dc.contributor.authorMichaluart, Pedro
dc.contributor.authorOkamoto, Oswaldo K.
dc.contributor.authorNunes, Fabio D.
dc.contributor.authorMoreira-Filho, Carlos A.
dc.contributor.authorTajara, Eloiza H.
dc.contributor.authorCury, P. M.
dc.contributor.authorFrizzera, A. P.Z.
dc.contributor.authorde Carvalho, M. B.
dc.contributor.authorSilva, A. M.A.
dc.contributor.authorAmar, A.
dc.contributor.authorBarbieri, R. B.
dc.contributor.authorBastos, A. U.
dc.contributor.authorCarvalho-Neto, P. B.
dc.contributor.authorCasemiro, A. F.
dc.contributor.authorChedid, H.
dc.contributor.authorChiappini, P. B.O.
dc.contributor.authorCorreia, L. A.
dc.contributor.authorCosta, A. C.W.
dc.contributor.authorCurioni, O. A.
dc.contributor.authorFranzi, S. A.
dc.contributor.authorGazito, D.
dc.contributor.authorGutierres, A. P.
dc.contributor.authorLehn, C. N.
dc.contributor.authorMartins, A. E.
dc.contributor.authorMercante, A. M.C.
dc.contributor.authorPorsani, A. F.
dc.contributor.authorRapoport, A.
dc.contributor.authorRossi, L.
dc.contributor.authorSantos, M.
dc.contributor.authorSouza, T. B.
dc.contributor.authorTakamori, J. T.
dc.contributor.authorDias-Neto, E.
dc.contributor.authorOjopi, E. P.B.
dc.contributor.authorDias, T. H.G.
dc.contributor.authorFigueiredo, D. L.A.
dc.contributor.authorMamede, R. C.M.
dc.contributor.authorFukuyama, E. E.
dc.contributor.authorGóis-Filho, J. F.
dc.contributor.authorCerione, M.
dc.contributor.authorCicco, R.
dc.contributor.authorSettani, F.
dc.contributor.authorValentim, P. J.
dc.contributor.authorYamagushi, F.
dc.contributor.authorCominato, M. L.
dc.contributor.authorMendes, G. S.
dc.contributor.authorPaiva, R.
dc.contributor.authorSilva, M. J.
dc.contributor.authorLeopoldino, A. M.
dc.contributor.authorSilva, F. A.M.
dc.contributor.authorMoyses, R. A.
dc.contributor.authorArap, S. S.
dc.contributor.authorAraújo, N. S.S.
dc.contributor.authorAraújo-Filho, V.
dc.contributor.authorBrandão, L. G.
dc.contributor.authorCernea, C. R.
dc.contributor.authorDurazzo, M.
dc.contributor.authorFerraz, A. R.
dc.contributor.authorGallo, J.
dc.contributor.authorGuimarães, P. E.M.
dc.contributor.authorMagalhães, R. P.
dc.contributor.authorMontenegro, F. L.M.
dc.contributor.authorSilva-Filho, G. B.
dc.contributor.authorSmith, R. B.
dc.contributor.authorStabenow, E.
dc.contributor.authorTavares, M. R.
dc.contributor.authorTurcano, R.
dc.contributor.authorVolpi, E. M.
dc.contributor.authorRamos, O.
dc.contributor.authorSilva, C.
dc.contributor.authorMoreira-Filho, C. A.
dc.contributor.authorNóbrega, F. G. [UNESP]
dc.contributor.authorNóbrega, M. P. [UNESP]
dc.contributor.authorCanto, A. L. [UNESP]
dc.contributor.authorMacarenco, R. [UNESP]
dc.contributor.authorMeneses, C. [UNESP]
dc.contributor.authorCorrea, P. M.S. [UNESP]
dc.contributor.authorBogossian, A. P. [UNESP]
dc.contributor.authorNunes, F. D.
dc.contributor.authorSouza, S. C.O.M.
dc.contributor.authorRodini, C. O.
dc.contributor.authorXavier, F. C.A.
dc.contributor.authorOkamoto, O. K.
dc.contributor.authorSerafini, L. N.
dc.contributor.authorSeverino, P.
dc.contributor.authorSilva, W. A.
dc.contributor.authorBrandão, R. M.
dc.contributor.authorKaneto, C. M.
dc.contributor.authorPinheiro, D. G.
dc.contributor.authorSantos, A. R.D.
dc.contributor.authorSilva, I. T.
dc.contributor.authorTarlá, M. V.C.
dc.contributor.authorSilveira, N. J.F.
dc.contributor.authorTajara, E. H.
dc.contributor.authorRodrigues-Lisoni, F. C.
dc.contributor.authorRodrigues, R. V.
dc.contributor.authorPolachini, G. M.
dc.contributor.authorVidotto, A.
dc.contributor.authorCunha, B. R.
dc.contributor.authorCarmona-Raphe, J.
dc.contributor.authorWünsch-Filho, V.
dc.contributor.authorCosta, A.
dc.contributor.authorFigueiredo, R. O.
dc.contributor.authorFortes, C. S.
dc.contributor.authorInamine, R.
dc.contributor.authorLópez, R. V.M.
dc.contributor.authorRodrigues, A. N.
dc.contributor.authorZago, M. A.
dc.contributor.institutionInstituto Israelita de Ensino e Pesquisa Albert Einstein
dc.contributor.institutionHospital Heliópolis
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto
dc.contributor.institutionFaculdade de Medicina
dc.contributor.institutionInstituto do Câncer Arnaldo Vieira de Carvalho
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto de Ensino e Pesquisa Albert Einstein
dc.contributor.institutionUNIVAP
dc.date.accessioned2022-04-29T08:44:18Z
dc.date.available2022-04-29T08:44:18Z
dc.date.issued2008-01-01
dc.description.abstractBackground: Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improvements in specificity and sensitivity of diagnosis. Results: Samples of primary OSCCs and their corresponding surgical margins were obtained from male patients during surgery and their gene expression profiles were screened using whole-genome microarray technology. Hierarchical clustering and Principal Components Analysis were used for data visualization and One-way Analysis of Variance was used to identify differentially expressed genes. Samples clustered mostly according to disease subsite, suggesting molecular heterogeneity within tumor stages. In order to corroborate our results, two publicly available datasets of microarray experiments were assessed. We found significant molecular differences between OSCC anatomic subsites concerning groups of genes presently or potentially important for drug development, including mRNA processing, cytoskeleton organization and biogenesis, metabolic process, cell cycle and apoptosis. Conclusion: Our results corroborate literature data on molecular heterogeneity of OSCCs. Differences between disease subsites and among samples belonging to the same TNM class highlight the importance of gene expression-based classification and challenge the development of targeted therapies.en
dc.description.affiliationCentro de Pesquisa Experimental Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.description.affiliationLaboratório de Biologia Molecular Hospital Heliópolis
dc.description.affiliationDepartamento de Cirurgia de Cabeça e Pescoço Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo
dc.description.affiliationDepartamento de Neurologia e Neurocirurgia Universidade Federal de São Paulo
dc.description.affiliationDepartamento de Estomatologia Faculdade de Odontologia Universidade de São Paulo
dc.description.affiliationDepartamento de Pediatria Faculdade de Medicina Universidade de São Paulo
dc.description.affiliationDepartamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto
dc.description.affiliationDepartamento de Genética e Biologia Evolutiva Instituto de Biociências Universidade de São Paulo
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina
dc.description.affiliationHospital Heliópolis
dc.description.affiliationDepartamento e Instituto de Psiquiatria Faculdade de Medicina USP
dc.description.affiliationServiço de Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Ribeirão Preto USP
dc.description.affiliationServiço de Cirurgia de Cabeça e Pescoço Instituto do Câncer Arnaldo Vieira de Carvalho
dc.description.affiliationDepartamento de Análises Clínicas Toxicológicas e Bromatológicas Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP
dc.description.affiliationDepartamento de Cirurgia de Cabeça e Pescoço Faculdade de Medicina USP
dc.description.affiliationDepartamento de Pediatria Faculdade de Medicina USP
dc.description.affiliationDepartamento de Biociências e Diagnóstico Bucal Faculdade de Odontologia UNESP
dc.description.affiliationDepartamento de Estomatologia Faculdade de Odontologia USP
dc.description.affiliationDepartamento de Neurologia e Neurocirurgia UNIFESP
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina de Ribeirão Preto USP
dc.description.affiliationInstituto de Ensino e Pesquisa Albert Einstein
dc.description.affiliationDepartamento de Genética Faculdade de Medicina de Ribeirão Preto USP
dc.description.affiliationCiências da Computação UNIVAP
dc.description.affiliationDepartamento de Biologia Molecular Faculdade de Medicina
dc.description.affiliationDepartamento de Epidemiologia Faculdade de Saúde Pública USP
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto USP
dc.description.affiliationUnespDepartamento de Biociências e Diagnóstico Bucal Faculdade de Odontologia UNESP
dc.identifierhttp://dx.doi.org/10.1186/1756-0500-1-113
dc.identifier.citationBMC Research Notes, v. 1.
dc.identifier.doi10.1186/1756-0500-1-113
dc.identifier.issn1756-0500
dc.identifier.scopus2-s2.0-77955596069
dc.identifier.urihttp://hdl.handle.net/11449/231244
dc.language.isoeng
dc.relation.ispartofBMC Research Notes
dc.sourceScopus
dc.titleGlobal gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsitesen
dc.typeArtigo

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