Effects to exposure of tobacco smoke and alcohol on the tongue and pharynx of rats

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dc.contributor.authorGarcia Martins, Regina Helena [UNESP]
dc.contributor.authorMarques Madeira, Sergio Luiz
dc.contributor.authorFabro, Alexandre Todorovic
dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.authorSemenzati, Graziela de Oliveira
dc.contributor.authorAlves, Karen Fernanda
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:36:38Z
dc.date.available2014-05-20T13:36:38Z
dc.date.issued2012-02-01
dc.description.abstractAim: To study in rats the effects of exposure to tobacco and alcohol on the mucosa of the tongue and pharynx.Material and methods: Forty adult Wistar rats were allocated into four groups of 10 animals each: GI (control), food and water "ad libitum"; GII (alcohol), 30% of ethanol diluted in drinking water and food "ad libitum"; GIII (tobacco), exposure to the smoke of 10 cigarettes/day, food and water "ad libitum"; GIV (alcohol and tobacco), simultaneous exposure to both agents. After 260 days, the animals were sacrificed. Tongue and pharynx were removed for histopathological analysis.Results: GI had the lowest tongue and pharynx histological scores. In GII, GIII, and GIV tongue samples revealed: apical cell hyperplasia (GII: 60%, GIII: 30%, GIV: 20%), basal cell hyperplasia (GII: 60%, GIII: 40%), hyperkeratosis (GII: 70%, GIII: 30%, GIV: 30%), dysplasia (GII: 60%, GIII: 60%, GIV: 50%), and apoptosis (GII: 60%, GIII: 40%, GIV: 60%). Pharynx samples revealed: apical cell hyperplasia (GII: 40%, GIII: 30%, GIV: 70%), basal cell hyperplasia (GII: 30%, GIII: 40%, GIV: 40%), hyperkeratosis (GII: 50%, GIII: 80%, GIV: 40%), and dysplasia (GII: 50%, GIII: 80%, GIV: 50%). Carcinoma in situ was detected in both sites.Conclusions: Alcohol and tobacco led to significant tongue and pharyngeal lesions that ranged from benign events to severe dysplasia. These findings confirm the deleterious effects of alcohol and tobacco on the airway mucosa.en
dc.description.affiliationSão Paulo State Univ, Botucatu Med Sch, Fac Med Botucatu, Dept Oftalmol, Botucatu, SP, Brazil
dc.description.affiliationBotucatu São Paulo State Univ UNESP, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Med Sch, Fac Med Botucatu, Dept Oftalmol, Botucatu, SP, Brazil
dc.description.affiliationUnespBotucatu São Paulo State Univ UNESP, Dept Pathol, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/15797
dc.format.extent153-160
dc.identifierhttp://dx.doi.org/10.3109/08958378.2011.649190
dc.identifier.citationInhalation Toxicology. London: Informa Healthcare, v. 24, n. 3, p. 153-160, 2012.
dc.identifier.doi10.3109/08958378.2011.649190
dc.identifier.issn0895-8378
dc.identifier.lattes8683290712226765
dc.identifier.lattes6077735918469284
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.urihttp://hdl.handle.net/11449/12599
dc.identifier.wosWOS:000300787300002
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofInhalation Toxicology
dc.relation.ispartofjcr1.819
dc.relation.ispartofsjr0,814
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLcoholen
dc.subjecttongueen
dc.subjectpharynxen
dc.subjecttobaccoen
dc.subjectratsen
dc.subjecthistologyen
dc.titleEffects to exposure of tobacco smoke and alcohol on the tongue and pharynx of ratsen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes8683290712226765
unesp.author.lattes6077735918469284
unesp.author.orcid0000-0002-7687-3161[3]
unesp.author.orcid0000-0002-8188-8149
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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