Would right atrial stretch inhibit sodium intake following GABAA receptor activation in the lateral parabrachial nucleus?

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dc.contributor.authorShimoura, Caroline Gusson [UNESP]
dc.contributor.authorBarbosa, Silas Pereira [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorDe Gobbi, Juliana Irani Fratucci [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:51Z
dc.date.available2014-05-27T11:30:51Z
dc.date.issued2013-10-11
dc.description.abstractThe knowledge of the mechanisms underlying circulating volume control may be achieved by stretching a balloon placed at the junction of the superior vena cava-right atrial junction (SVC-RAJ). We investigated whether the inflation of a balloon at the SVC-RAJ inhibits the intake of 0.3M NaCl induced by GABAA receptor activation in the lateral parabrachial nucleus (LPBN) in euhydrated and satiated rats. Male Wistar rats (280-300g) with bilateral stainless steel LPBN cannulae and balloons implanted at the SVC-RAJ were used. Bilateral injections of the GABAA receptor agonist muscimol (0.5ηmol/0.2l) in the LPBN with deflated balloons increased intake of 0.3M NaCl (30.1±3.9 vs. saline: 2.2±0.7)ml/210min, n=8) and water (17.7±1.9 vs. saline: 2.9±0.5ml/210min). Conversely, 0.3M NaCl (27.8±2.1ml/210min) and water (22.8±2.3ml/210min) intake were not affected in rats with inflated balloons at the SVC-RAJ. The results show that sodium and water intake induced by muscimol injected into the LPBN was not affected by balloon inflation at the SVC-RAJ. We suggest that the blockade of LPBN neuronal activity with muscimol injections impairs inhibitory mechanisms activated by signals from cardiopulmonary volume receptors determined by balloon inflation. © 2013 The Authors.en
dc.description.affiliationDepartment of Physiology Institute of Bioscience São Paulo State University (UNESP), 18618-000 Botucatu, SP
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP), 14801-903 Araraquara, SP
dc.description.affiliationUnespDepartment of Physiology Institute of Bioscience São Paulo State University (UNESP), 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP), 14801-903 Araraquara, SP
dc.format.extent121-125
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2013.08.005
dc.identifier.citationNeuroscience Letters, v. 553, p. 121-125.
dc.identifier.doi10.1016/j.neulet.2013.08.005
dc.identifier.file2-s2.0-84884377371.pdf
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.scopus2-s2.0-84884377371
dc.identifier.urihttp://hdl.handle.net/11449/76832
dc.identifier.wosWOS:000326008700023
dc.language.isoeng
dc.relation.ispartofNeuroscience Letters
dc.relation.ispartofjcr2.159
dc.relation.ispartofsjr0,946
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCardiopulmonary volume receptors
dc.subjectCirculating volume
dc.subjectGABAA
dc.subjectLateral parabrachial nucleus
dc.subjectRight atrial stretch
dc.subjectSodium intake
dc.subject4 aminobutyric acid A receptor
dc.subjectmuscimol
dc.subjectsilastic
dc.subjectstainless steel
dc.subjectanimal experiment
dc.subjectballoon catheter
dc.subjectballoon embolization
dc.subjectfluid intake
dc.subjectmale
dc.subjectmicrophotography
dc.subjectnonhuman
dc.subjectparabrachial nucleus
dc.subjectpriority journal
dc.subjectrat
dc.subjectsodium intake
dc.subjectsuperior cava vein
dc.titleWould right atrial stretch inhibit sodium intake following GABAA receptor activation in the lateral parabrachial nucleus?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.orcid0000-0003-1167-4441[3]
unesp.author.orcid0000-0001-5845-0475[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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