Effectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challenge

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dc.contributor.authorda Silva, Ana Paula Pereira [UNESP]
dc.contributor.authorGonçalves, Rafael Simões
dc.contributor.authorBorges, Ana Flávia Sanches
dc.contributor.authorBedranrusso, Ana Karina
dc.contributor.authorShinohara, Mirela Sanae [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:57:54Z
dc.date.available2018-12-11T16:57:54Z
dc.date.issued2015-01-01
dc.description.abstractDental caries is considered a disease of high prevalence and a constant problem in public health. Proanthocyanidins (PAs) are substances that have been the target of recent studies aiming to control or treat caries. Objective: The aim of this in vitro study was to evaluate the efficacy of a treatment with grape seed extract, under cariogenic challenge, to minimize or even prevent the onset of caries in the enamel and dentin. Material and Methods: Blocks of enamel and dentin (6.0x6.0 mm) were obtained from bovine central incisors, polished, and selected by analysis of surface microhardness (SH). The blocks were randomly divided into 3 groups (n=15), according to the following treatments: GC (control), GSE (grape seed extract), GF (fluoride – 1,000 ppm). The blocks were subjected to 6 daily pH cycles for 8 days. Within the daily cycling, the specimens were stored in buffered solution. The blocks were then analyzed for perpendicular and surface hardness and polarized light microscopy. Results: The means were subjected to statistical analysis using the ANOVA and Fisher’s PLSD tests (p<0.05). For enamel SH, GF showed the highest hardness values. In the dentin, GF was also the one that showed higher hardness values, followed by GSE. Regarding the cross-sectional hardness values, all groups behaved similarly in both the enamel and dentin. The samples that were treated with GSE and fluoride (GF) showed statistically higher values than the control. Conclusion: Based on the data obtained in this in vitro study, it is suggested that grape seed extract inhibits demineralization of artificial carious lesions in both the enamel and dentin, but in a different scale in each structure and in a smaller scale when compared to fluoride.en
dc.description.affiliationDepartment of Restorative Dentistry, Araçatuba Dental School, UNESP – Univ. Estadual Paulista
dc.description.affiliationDepartment of Dentistry, Endodontic and Dental Materials, Bauru School of Dentistry, University of São Paulo
dc.description.affiliationDepartment of Restorative Dentistry, College of Dentistry, University of Illinois
dc.description.affiliationUnespDepartment of Restorative Dentistry, Araçatuba Dental School, UNESP – Univ. Estadual Paulista
dc.format.extent295-301
dc.identifierhttp://dx.doi.org/10.1590/1678-775720140304
dc.identifier.citationJournal of Applied Oral Science, v. 23, n. 3, p. 295-301, 2015.
dc.identifier.doi10.1590/1678-775720140304
dc.identifier.fileS1678-77572015000300302.pdf
dc.identifier.issn1678-7765
dc.identifier.issn1678-7757
dc.identifier.scieloS1678-77572015000300302
dc.identifier.scopus2-s2.0-84937879157
dc.identifier.urihttp://hdl.handle.net/11449/171956
dc.language.isoeng
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.ispartofsjr0,645
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDental caries
dc.subjectDental enamel
dc.subjectDentin
dc.subjectHardness
dc.subjectProanthocyanidins
dc.titleEffectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challengeen
dc.typeArtigo

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Artigos - Odontologia Restauradora - FOA