Maternal Western Style Diet Increases Susceptibility to Chemically-Induced Mammary Carcinogenesis in Female Rats Offspring

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dc.contributor.authorLopes, Gisele A. D. [UNESP]
dc.contributor.authorFan, William Y. C. [UNESP]
dc.contributor.authorCiol, Heloisa [UNESP]
dc.contributor.authorBidinotto, Lucas T.
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBarretos Canc Hosp
dc.contributor.institutionDr Paulo Prata FACISB
dc.date.accessioned2015-03-18T15:54:33Z
dc.date.available2015-03-18T15:54:33Z
dc.date.issued2014-11-17
dc.description.abstractThe present study investigated whether maternal exposure to western style diet (WD) increases susceptibility to mammary carcinogenesis induced by N-methyl-N-nitrosourea (MNU) in female offspring. Pregnant female Sprague-Dawley rats received WD diet or control diet from gestational day 12 until postnatal day (PND) 21. At PND 21, female offspring received a single dose of MNU (50mg/kg body weight) and were fed chow diet until PND 110. Mammary gland structures were assessed on whole-mount preparations in the offspring at PND 21, and tumor morphology was examined at PND 110. Immunohistochemical analysis for cell proliferation (PCNA), apoptosis (cleaved caspase-3) and estrogen receptor alpha (ER-alpha) was performed in mammary terminal end buds (TEBs) at PND 21, and PCNA, ER-alpha, and p63 analysis in mammary tumors at PND 110. Maternal WD intake induced a significant increase in the number of TEBs (P = 0.024) and in PCNA labeling index (P < 0.020) in the mammary glands at PND 21. Tumor multiplicity, tumor weight, and PCNA labeling indexes were significantly higher in the WD offspring than that of the control offspring (P < 0.05). These findings indicate that maternal western style diet potentially enhanced the development of mammary tumors induced by MNU in female offspring, possibly by affecting the mammary gland differentiation.en
dc.description.affiliationSao Paulo State Univ, Botucatu Med Sch, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, Botucatu Biosci Inst, Dept Morphol, Sao Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo, Brazil
dc.description.affiliationDr Paulo Prata FACISB, Barretos Sch Hlth Sci, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Med Sch, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Biosci Inst, Dept Morphol, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFUNDUNESP: 0016/010/13-PROPe/CDC
dc.description.sponsorshipIdFAPESP: 07/57408-0
dc.description.sponsorshipIdFAPESP: 11/06669-4
dc.description.sponsorshipIdCNPq: 2009/11026
dc.format.extent1293-1303
dc.identifierhttp://dx.doi.org/10.1080/01635581.2014.956256
dc.identifier.citationNutrition And Cancer-an International Journal. Abingdon: Routledge Journals, Taylor & Francis Ltd, v. 66, n. 8, p. 1293-1303, 2014.
dc.identifier.doi10.1080/01635581.2014.956256
dc.identifier.issn0163-5581
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/116937
dc.identifier.wosWOS:000344863600004
dc.language.isoeng
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofNutrition And Cancer-an International Journal
dc.relation.ispartofjcr2.261
dc.relation.ispartofsjr0,745
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleMaternal Western Style Diet Increases Susceptibility to Chemically-Induced Mammary Carcinogenesis in Female Rats Offspringen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderRoutledge Journals, Taylor & Francis Ltd
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0002-6909-8347[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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