Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis

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dc.contributor.authorSpinnato, Joseph A.
dc.contributor.authorFreire, Salvio
dc.contributor.authorPinto e Silva, Joao Luiz
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorMartins-Costa, Sergio
dc.contributor.authorKoch, Matthew A.
dc.contributor.authorGoco, Norman
dc.contributor.authorSantos, Cleide de Barros
dc.contributor.authorCecatti, Jose Guilherme
dc.contributor.authorCosta, Roberto [UNESP]
dc.contributor.authorRamos, Jose Geraldo
dc.contributor.authorMoss, Nancy
dc.contributor.authorSibai, Baha M.
dc.contributor.institutionUniv Cincinnati
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionRTI Int
dc.contributor.institutionNICHHD
dc.date.accessioned2014-05-20T13:35:31Z
dc.date.available2014-05-20T13:35:31Z
dc.date.issued2008-10-01
dc.description.abstractOBJECTIVE: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM).STUDY DESIGN: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 12(0/7) and 19(6/7) weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo.RESULTS: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group.CONCLUSION: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM.en
dc.description.affiliationUniv Cincinnati, Coll Med, Cincinnati, OH USA
dc.description.affiliationUniversidade Federal de Pernambuco (UFPE), Hosp Clin, Recife, PE, Brazil
dc.description.affiliationUniv Estadual Campinas, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Hosp & Clin, Porto Alegre, RS, Brazil
dc.description.affiliationRTI Int, Res Triangle Pk, NC USA
dc.description.affiliationNICHHD, Bethesda, MD 20892 USA
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu, SP, Brazil
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.1016/j.ajog.2008.07.011
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology. New York: Mosby-elsevier, v. 199, n. 4, p. 8, 2008.
dc.identifier.doi10.1016/j.ajog.2008.07.011
dc.identifier.issn0002-9378
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12232
dc.identifier.wosWOS:000260045700042
dc.language.isoeng
dc.publisherMosby-elsevier
dc.relation.ispartofAmerican Journal of Obstetrics and Gynecology
dc.relation.ispartofjcr5.732
dc.relation.ispartofsjr2,700
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantioxidantsen
dc.subjectpremature rupture of the membranesen
dc.subjectprematurityen
dc.subjectpreventionen
dc.subjectvitamin Cen
dc.subjectvitamin Een
dc.titleAntioxidant supplementation and premature rupture of the membranes: a planned secondary analysisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby-elsevier
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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