Conventional versus biological therapy for prevention of postoperative endoscopic recurrence in patients with Crohn's disease: an international, multicenter, and observational study

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dc.contributor.authorKotze, Paulo Gustavo
dc.contributor.authorSpinelli, Antonino
dc.contributor.authorda Silva, Rodolff Nunes
dc.contributor.authorde Barcelos, Ivan Folchini
dc.contributor.authorTeixeira, Fábio Vieira
dc.contributor.authorSaad-Hossne, Rogério [UNESP]
dc.contributor.authorde Albuquerque, Idblan Carvalho
dc.contributor.authorOlandoski, Marcia
dc.contributor.authorda Silva Kotze, Lorete Maria
dc.contributor.authorSuzuki, Yasuo
dc.contributor.authorYamada, Akihiro
dc.contributor.authorTakeuchi, Ken
dc.contributor.authorSacchi, Matteo
dc.contributor.authorYamamoto, Takayuki
dc.contributor.institutionColorectal Surgery Unit, Catholic University of Paraná, Curitiba, PR, Brazil.
dc.contributor.institutionColorectal and IBD Surgery Unit, Humanitas Research Hospital, University of Milan, Milan, Italy.
dc.contributor.institutionClínica Gastrosaúde, Marília, SP, Brazil.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInflammatory Bowel Disease Outpatient Clinic, Heliópolis Hospital, São Paulo, SP, Brazil.
dc.contributor.institutionGastroenterology Unit, Sakura Hospital, Toho University, Chiba, Japan.
dc.contributor.institutionInflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.
dc.date.accessioned2015-12-07T15:34:58Z
dc.date.available2015-12-07T15:34:58Z
dc.date.issued2015
dc.description.abstractPostoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn's disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice. The MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecal resection, from 7 referral centers in 3 different countries. All consecutive patients who underwent ileocecal resections between 2008 and 2012 and in whom colonoscopies had been performed up to 12 months after surgery, were included. Recurrence was defined as Rutgeerts' score ≥i2. The patients were allocated to either biological or conventional therapy after surgery, and PER rates were compared between the groups. Initially, 231 patients were evaluated, and 63 were excluded. Of the 168 patients in the database, 96 received anti-tumor necrosis factor agents and 72 were treated with conventional therapy after resection. The groups were comparable regarding age, gender, and perianal disease. There was longer disease duration, more previous resections, and more open surgical procedures in patients on biologicals postoperatively. PER was identified in 25/96 (26%) patients on biological therapy and in 24/72 (33.3%) patients on conventional therapy (P=0.310). In this retrospective observational analysis from an international database, no difference was observed between biological and conventional therapy in preventing PER after ileocecal resections in CD patients.en
dc.description.affiliationColorectal Surgery Unit, Catholic University of Paraná, Curitiba, PR, Brazil.
dc.description.affiliationColorectal and IBD Surgery Unit, Humanitas Research Hospital, University of Milan, Milan, Italy.
dc.description.affiliationClínica Gastrosaúde, Marília, SP, Brazil.
dc.description.affiliationDigestive Surgery Unit, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu, SP, Brazil.
dc.description.affiliationInflammatory Bowel Disease Outpatient Clinic, Heliópolis Hospital, São Paulo, SP, Brazil.
dc.description.affiliationGastroenterology Unit, Sakura Hospital, Toho University, Chiba, Japan.
dc.description.affiliationInflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.
dc.description.affiliationUnespDigestive Surgery Unit, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu, SP, Brazil.
dc.format.extent259-265
dc.identifierhttp://dx.doi.org/10.5217/ir.2015.13.3.259
dc.identifier.citationIntestinal Research, v. 13, n. 3, p. 259-265, 2015.
dc.identifier.doi10.5217/ir.2015.13.3.259
dc.identifier.issn1598-9100
dc.identifier.pmcPMC4479741
dc.identifier.pubmed26131001
dc.identifier.urihttp://hdl.handle.net/11449/131409
dc.language.isoeng
dc.publisherIntestinal Research
dc.relation.ispartofIntestinal Research
dc.relation.ispartofsjr1,074
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectCrohn diseaseen
dc.subjectRecurrenceen
dc.subjectTumor necrosis factor-alphaen
dc.titleConventional versus biological therapy for prevention of postoperative endoscopic recurrence in patients with Crohn's disease: an international, multicenter, and observational studyen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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