A Catuama e o bilobalide na regeneração nervosa periférica de ratos submetidos à secção do nervo isquiático

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dc.contributor.authorPereira, Rodrigo Norberto
dc.contributor.authorDelistoianov, Nádia
dc.contributor.authorPerotta, João Henrique
dc.contributor.authorMagalhães, Geórgia Modé
dc.contributor.authorFavoretto, Samantha Mesquita
dc.contributor.authorAlessi, Antonio Carlos [UNESP]
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)
dc.contributor.institutionCentro de Ciências Agrárias, Ambientais e Biológicas (CCAAB), Universidade Federal do Recôncavo da Bahia (UFRB)
dc.contributor.institutionUniversidade de Franca (Unifran)
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:55:45Z
dc.date.accessioned2014-12-03T13:11:30Z
dc.date.available2018-12-11T16:55:45Z
dc.date.available2014-12-03T13:11:30Z
dc.description.abstractThe Catuama((R)) is composed of four Brazilian plants extracts (Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides e Zingiber officinale). The Catuama((R)) is known as having neuroprotector, anti-inflammatory, antioxidant and antidepressant effects. Bilobalide, extracted from leaves of Ginkgo biloba, is known by its neuroprotective effect in the central and peripheral nervous systems. The present study evaluates the effect of Catuama((R)) and bilobalide on peripheral nerve regeneration in rats following a sciatic nerve section. Sciatic nerve of forty adult rats was transected with a 10-mm gap and the proximal and distal nerve stumps were fixed in a silicone tube filled with liquid collagen. The animals were divided into four groups: the control group (A), two groups treated with Catuama((R)) by gavage along 28 days after the surgery in different doses of 100 (B) and 400mg. kg(-1) (C) and the group using 200 mu M bilobalide (D) associated with the liquid collagen in the silicone tube. Evaluations were done by a walk test on the first, fifth and tenth week after the surgery. Electrophysiological stimulation and quantitative and qualitative histological analyses of the sciatic nerve and gastrocnemius muscle were also performed on the tenth week after the surgery. All groups showed good regeneration but no statistical difference was found between treatments and control groups (P > 0.05).en
dc.description.affiliationDepartamento de Medicina Veterinária, Universidade Federal de Lavras (UFLA), CP 3037, 37200-000, Lavras, MG
dc.description.affiliationCentro de Ciências Agrárias, Ambientais e Biológicas (CCAAB), Universidade Federal do Recôncavo da Bahia (UFRB), Cruz das Almas, BA
dc.description.affiliationUniversidade de Franca (Unifran), Franca, SP
dc.description.affiliationCCA, UFPB, Areia, PB
dc.description.affiliationDepartamento de Patologia Veterinária, Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.description.affiliationUnespDepartamento de Patologia Veterinária, Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.format.extent854-860
dc.identifierhttp://dx.doi.org/10.1590/S0103-84782014000500016
dc.identifier.citationCiencia Rural. Santa Maria: Univ Federal Santa Maria, v. 44, n. 5, p. 854-860, 2014.
dc.identifier.doi10.1590/S0103-84782014000500016
dc.identifier.fileWOS000335217000015.pdf
dc.identifier.issn1678-4596
dc.identifier.issn0103-8478
dc.identifier.scopus2-s2.0-84899426038
dc.identifier.urihttp://hdl.handle.net/11449/180408
dc.identifier.wosWOS:000335217000015
dc.language.isoeng
dc.language.isopor
dc.publisherUniv Federal Santa Maria
dc.relation.ispartofCiência Rural
dc.relation.ispartofjcr0.525
dc.relation.ispartofsjr0,337
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.sourceWeb of Science
dc.subjectCollagen
dc.subjectPeripheral nerve repair
dc.subjectPhytotherapy
dc.subjectSilicone tube
dc.titleA Catuama e o bilobalide na regeneração nervosa periférica de ratos submetidos à secção do nervo isquiáticopt
dc.title.alternativeCatuama and bilobalide on peripheral nerve regeneration in rats following sciatic nerve sectionen
dc.typeArtigo
dcterms.rightsHolderUniv Federal Santa Maria
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Patologia Veterinária - FCAV