Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population

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dc.contributor.authorSampaio-Barros, Percival D.
dc.contributor.authorConde, Roseneide A.
dc.contributor.authorDonadi, Eduardo A. [UNESP]
dc.contributor.authorBonWglioli, Rubens
dc.contributor.authorCostallat, Lilian T. L.
dc.contributor.authorSamara, Adil M.
dc.contributor.authorBertolo, Manoel B.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:52:58Z
dc.date.available2015-03-18T15:52:58Z
dc.date.issued2008-03-01
dc.description.abstractThis retrospective study analyzed the HLA-B*27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990-2006, and compared the data with that observed in other patients with spondyloarthropathies followed at the same institution. Eight cases were associated to gastrointestinal infection, eight cases to previous urethritis, and four cases presented no established preceding infection. HLA-B*27 alleles were typed by polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes (HLA-B*2701 to HLA-B*2721). They were compared to a group of 108 patients with ankylosing spondylitis (AS), 40 with undifferentiated spondyloarthropathy (uSpA) and 111 healthy controls. Among the 20 patients, 17 were HLA-B*27 positive (85%). Two HLA-B*27 alleles were observed: HLA-B*2705 (65%) and HLA-B*2702 (35%). In the other spondyloarthropathies, the observed alleles were HLA-B*2705 (90% in AS and 92.5% in uSpA), HLA-B*2702 (8% in AS and 5% in uSpA), HLA-B*2704 (1% in AS and 2.5% in uSpA) and HLA-B*2713 (1% in AS). Among the 111 healthy controls, 80% presented HLA-B*2705, followed by HLA-B*2702 in 10%, HLA-B*2703 in 6%, HLA-B*2707 in 3% and HLA-B*2713 in 1%. Concluding, in the HLA-B*27 positive patients with RS in this study there was predominance of HLA-B*2705 allele, in a lower frequency than that observed in patients with other spondyloarthropathies and healthy controls.en
dc.description.affiliationUniv Estadual Campinas, Fac Med, Dept Internal Med, Rheumatol Unit,FCM UNICAMP, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationState Univ Sao Paulo Ribeirao Preto, Rheumatol Unit, Ribeirao Preto, SP, Brazil
dc.description.affiliationState Univ Sao Paulo Ribeirao Preto, Lab Mol Immunol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo Ribeirao Preto, Rheumatol Unit, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo Ribeirao Preto, Lab Mol Immunol, Ribeirao Preto, SP, Brazil
dc.format.extent483-486
dc.identifierhttp://dx.doi.org/10.1007/s00296-007-0441-3
dc.identifier.citationRheumatology International. New York: Springer, v. 28, n. 5, p. 483-486, 2008.
dc.identifier.doi10.1007/s00296-007-0441-3
dc.identifier.issn0172-8172
dc.identifier.urihttp://hdl.handle.net/11449/116256
dc.identifier.wosWOS:000253204100013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofRheumatology International
dc.relation.ispartofjcr1.952
dc.relation.ispartofsjr0,906
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectReiter syndromeen
dc.subjectHLA-B27en
dc.subjectepidemiologyen
dc.titleFrequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control populationen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

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