Lycopene supplementation reduces TNF-alpha via RAGE in the kidney of obese rats

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dc.contributor.authorPierine, D. T. [UNESP]
dc.contributor.authorNavarro, M. E. L. [UNESP]
dc.contributor.authorMinatel, I. O. [UNESP]
dc.contributor.authorLuvizotto, R. A. M. [UNESP]
dc.contributor.authorNascimento, A. F. [UNESP]
dc.contributor.authorFerreira, A. L. A. [UNESP]
dc.contributor.authorYeum, K-J
dc.contributor.authorCorrea, C. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts University
dc.contributor.institutionKonkuk University
dc.date.accessioned2015-11-03T15:27:43Z
dc.date.available2015-11-03T15:27:43Z
dc.date.issued2014-11-01
dc.description.abstractThe kidney is a target organ for injuries caused by advanced glycation end products (AGEs) in obesity. The receptor of AGEs (RAGE) is proinflammatory and appears to have a role in the pathogenesis of renal disease due to obesity.OBJECTIVE: The aim was to verify the effect of obesity on renal damage and the effect of lycopene on these complicationsDESIGN AND METHODS: Male Wistar rats were randomly assigned to receive a control diet (C, n = 7) or a high-fat diet plus sucrose (HD+S, n = 14) for 6 weeks. After this period, the HD+S animals were randomized into two groups: HD+S (n = 7) and HD+S supplemented with lycopene (HD+S+L, n = 7). The animals received maize oil (C and HD+S) or lycopene (HD+S+L) for a 6-week period.RESULTS: The HD+S and HD+S+L animals demonstrated insulin resistance (OGTT glucose after 150 min; C: 117.6 +/- 3.9 < HD+S: 138.1 +/- 5.1 = HD+S+L: 137.8 +/- 5.2 mg dl(-1); P = 0.01); however, no changes were seen in fasting glucose, plasma lipids, blood pressure or renal function. Renal concentrations of RAGE and TNF-alpha increased in the HD+S group and lycopene supplementation restored these to control group values (RAGE: C: 3.1 +/- 0.3 = DH+S+L: 3.1 +/- 0.3 < DH+S: 3.6 +/- 0.4 mu g g(-1); P = 0.014; TNF-alpha: C: 227.8 +/- 2.7 = DH+S+L: 227.4 +/- 2.2 < DH+S: 238.7 +/- 3.0 pg/ml; P = 0.014).CONCLUSIONS: Lycopene may be beneficial in the prevention and treatment of oxidative stress and inflammation in the kidney due to obesity.en
dc.description.affiliationJean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
dc.description.affiliationFood and Nutrition Major, Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Glocal Campus, Seoul, South Korea.
dc.description.affiliationUnespPathology Department, Botucatu Medical School—São Paulo State University—UNESP, Botucatu, Brazil
dc.description.affiliationUnespInternal Medicine Department, Botucatu Medical School—São Paulo State University—UNESP, Botucatu, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2010/06100-9
dc.description.sponsorshipIdFAPESP: 2011/14132-0
dc.description.sponsorshipIdCAPES: 022/11
dc.description.sponsorshipIdCAPES: BEX: 9847/11-1
dc.format.extent1-6
dc.identifierhttp://www.nature.com/nutd/journal/v4/n11/full/nutd201439a.html
dc.identifier.citationNutrition & Diabetes. London: Nature Publishing Group, v. 4, p. 1-6, 2014.
dc.identifier.doi10.1038/nutd.2014.39
dc.identifier.issn2044-4052
dc.identifier.lattes2940051650846541
dc.identifier.urihttp://hdl.handle.net/11449/129909
dc.identifier.wosWOS:000348501900001
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofNutrition & Diabetes
dc.relation.ispartofjcr2.742
dc.relation.ispartofsjr1,628
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleLycopene supplementation reduces TNF-alpha via RAGE in the kidney of obese ratsen
dc.typeArtigo
dcterms.rightsHolderNature Publishing Group
unesp.author.lattes2940051650846541[6]
unesp.author.orcid0000-0002-9922-2871[3]
unesp.author.orcid0000-0002-5267-1127[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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