A topical cell therapy approach for diabetic chronic ulcers: Effects of mesenchymal stromal cells associated with platelet-rich plasma

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dc.contributor.authorStessuk, Talita
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.authorColpas, Paula Tavares
dc.contributor.authorMartins Alves, Paulo César
dc.contributor.authorRehder, Jussara
dc.contributor.authorBosnardo, Carla Aparecida Faccio
dc.contributor.authorGuillaumon, Ana Terezinha
dc.contributor.authorForte, Andresa
dc.contributor.authorPuzzi, Maria Beatriz
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionCordCell CellTherapy
dc.date.accessioned2020-12-12T01:15:16Z
dc.date.available2020-12-12T01:15:16Z
dc.date.issued2020-01-01
dc.description.abstractBackground: Diabetic cutaneous ulcers are subjected to several physiological and biochemical defects, which contribute to wound chronicity and therapeutic failure. Platelet-rich plasma (PRP) has been used for stimulating tissue regeneration, and mesenchymal stromal cells (MSCs) have demonstrated therapeutic properties in all phases of skin regeneration in cell therapy studies. Aims: The objective of this study was to evaluate the therapeutic effects related to the use of a biomembrane composed of autologous MSCs and PRP on chronic wounds of diabetic patients (pre-post pilot study). Patients/Methods: Six diabetic patients with chronic wounds for more than 6 months were subjected to adipose tissue collection for isolation of MSCs, blood collection for PRP preparation, and topical administration of a biomembrane of MSCs and PRP on each chronic wound. The statistical difference regarding the evolution of ulcers was calculated by means of paired t test. Results: There was granulation tissue formation starting from 7 days after topical application. Total re-epithelialization occurred in 5 of the 9 lesions treated, and the mean wound healing rate (WHR) was 74.55% (±32.55%) after 90 days. No cicatricial hypertrophy or retraction was observed. Conclusion: Mesenchymal stromal cells topical therapy associated with PRP is well-tolerated and able to provide a reduction in ulcer area of diabetic chronic wounds.en
dc.description.affiliationUniversity of São Paulo USP
dc.description.affiliationSão Paulo State University UNESP–Campus de Assis
dc.description.affiliationUniversity of Campinas UNICAMP
dc.description.affiliationCordCell CellTherapy
dc.description.affiliationUnespSão Paulo State University UNESP–Campus de Assis
dc.identifierhttp://dx.doi.org/10.1111/jocd.13321
dc.identifier.citationJournal of Cosmetic Dermatology.
dc.identifier.doi10.1111/jocd.13321
dc.identifier.issn1473-2165
dc.identifier.issn1473-2130
dc.identifier.scopus2-s2.0-85079465799
dc.identifier.urihttp://hdl.handle.net/11449/198524
dc.language.isoeng
dc.relation.ispartofJournal of Cosmetic Dermatology
dc.sourceScopus
dc.subjectcell therapy
dc.subjectdiabetes mellitus
dc.subjectmesenchymal stromal cells
dc.subjectplatelet-rich plasma
dc.subjectwound healing
dc.titleA topical cell therapy approach for diabetic chronic ulcers: Effects of mesenchymal stromal cells associated with platelet-rich plasmaen
dc.typeArtigo
unesp.author.orcid0000-0002-4254-209X[1]
unesp.author.orcid0000-0002-7645-5891[2]
unesp.author.orcid0000-0001-8248-7884[9]

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