Blood pressure and renal injury in dogs with visceral leishmaniasis

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dc.contributor.authorSousa, Marlos G.
dc.contributor.authorLima, Amanda B.G.
dc.contributor.authorAraújo, Cristiane R.A.
dc.contributor.authorSilva, Vinícius B.C.
dc.contributor.authorRamos, Adriano T.
dc.contributor.authorMachado, Gisele F. [UNESP]
dc.contributor.authorMelo, Guilherme D. [UNESP]
dc.contributor.authorCarareto, Roberta
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Federal do Tocantins (UFT)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:45:25Z
dc.date.available2018-12-11T16:45:25Z
dc.date.issued2016-01-01
dc.description.abstractSystemic hypertension is known to be a common consequence of chronic renal disease, which is frequently diagnosed in dogs with visceral leishmaniasis. Although many veterinary investigations have looked at the renal injury caused by Leishmania spp., the role played by this complication in the development of arterial hypertension documented in some animals with visceral leishmaniasis is not completely understood. In this study, 18 adult dogs with naturally-occurring visceral leishmaniasis and varying clinical signs underwent an indirect blood pressure measurement. Also, sera and spot urine were used for laboratory tests. The median systolic blood pressure was 135.2mmHg (95% confidence interval: 128.5-147.7), median mean arterial pressure was 105.8mmHg (98.3-110.4), and median diastolic arterial pressure was 88.5mmHg (77.8-92.5). No differences existed between asymptomatic and symptomatic animals regarding arterial pressure, and no correlations were documented between blood pressure and serum creatinine, blood urea, urine protein-to-creatinine ratio, urine specific gravity, and the fractional excretion of sodium and potassium. Although an association between hypertension and the identification of inflammation on histopathology could not be demonstrated in hypertensive animals, the assessment of kidney samples from 12 dogs indicated mild inflammation with a lymphoplasmacytic infiltrate (6/12), moderate inflammation with multifocal lymphoplasmacytic and histiocytic infiltrates (3/12), and multifocal degeneration and protein casts (2/12). Anti-Leishmania spp. immunohistochemistry assays stained the renal epithelium in 2/12 of the animals. Even though mild systemic hypertension was documented in a small subset of animals, no relationship between the severity of clinical signs and hypertension could be anticipated.en
dc.description.affiliationUniversidade Federal do Paraná (UFPR) Rua dos Funcionários 1540 Bairro Cabral
dc.description.affiliationEscola de Medicina Veterinária e Zootecnia (EMVZ) Universidade Federal do Tocantins (UFT), BR-153 Km 112, Campus EMVZ
dc.description.affiliationUniversidade Federal de Santa Catarina (UFSC) Rodovia Ulysses Gaboardi Km 3, Campus UFSC
dc.description.affiliationDepartamento de Clínica Cirurgia e Reprodução Animal Universidade Estadual Paulista (Unesp), Rua Clóvis Pestana 793, Ipanema
dc.description.affiliationUnespDepartamento de Clínica Cirurgia e Reprodução Animal Universidade Estadual Paulista (Unesp), Rua Clóvis Pestana 793, Ipanema
dc.format.extent857-863
dc.identifierhttp://dx.doi.org/10.1590/S0100-736X2016000900011
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 36, n. 9, p. 857-863, 2016.
dc.identifier.doi10.1590/S0100-736X2016000900011
dc.identifier.fileS0100-736X2016000900857.pdf
dc.identifier.issn1678-5150
dc.identifier.issn0100-736X
dc.identifier.scieloS0100-736X2016000900857
dc.identifier.scopus2-s2.0-85008700670
dc.identifier.urihttp://hdl.handle.net/11449/169336
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectDog
dc.subjectGlomerulopathy
dc.subjectHypertension
dc.subjectKidney
dc.subjectLeishmaniasis
dc.subjectParasitic disease
dc.subjectProteinuria
dc.titleBlood pressure and renal injury in dogs with visceral leishmaniasisen
dc.typeArtigo

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