Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells

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dc.contributor.authorOkamoto-Okubo, Celina Emiko [UNESP]
dc.contributor.authorCassu, Renata Navarro
dc.contributor.authorJoaquim, Jean Guilherme Fernandes [UNESP]
dc.contributor.authorDos Reis Mesquita, Luciane [UNESP]
dc.contributor.authorRahal, Sheila Canevese [UNESP]
dc.contributor.authorOliveira, Hugo S Salvador [UNESP]
dc.contributor.authorTakahira, Regina [UNESP]
dc.contributor.authorArruda, Isadora [UNESP]
dc.contributor.authorMaia, Leandro [UNESP]
dc.contributor.authorda CRUZ LANDIM, Fernanda [UNESP]
dc.contributor.authorLuna, Stelio Pacca Loureiro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista
dc.date.accessioned2021-06-25T11:01:15Z
dc.date.available2021-06-25T11:01:15Z
dc.date.issued2021-01-01
dc.description.abstractThis prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment.en
dc.description.affiliationDepartment of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science
dc.description.affiliationDepartment of Veterinary Surgery and Anesthesiology Faculty of Veterinary Medicine Universidade do Oeste Paulista
dc.description.affiliationUnespDepartment of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science
dc.format.extent881-888
dc.identifierhttp://dx.doi.org/10.1292/jvms.20-0730
dc.identifier.citationJournal of Veterinary Medical Science, v. 83, n. 5, p. 881-888, 2021.
dc.identifier.doi10.1292/jvms.20-0730
dc.identifier.issn1347-7439
dc.identifier.issn0916-7250
dc.identifier.scopus2-s2.0-85106882302
dc.identifier.urihttp://hdl.handle.net/11449/207799
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Medical Science
dc.sourceScopus
dc.subjectCanine
dc.subjectHip dysplasia
dc.subjectMesenchymal stem cells
dc.subjectOsteoarthritis
dc.subjectPlatelet-rich plasma
dc.titleChronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cellsen
dc.typeArtigo

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