Developing new radiotherapy techniques using linac based gamma radiation sources

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dc.contributor.authorArruda-Neto, J. D T
dc.contributor.authorBittencourt-Oliveira, M. C.
dc.contributor.authorSchenberg, A. C G
dc.contributor.authorSilva, E. C.
dc.contributor.authorMesa, J.
dc.contributor.authorRodrigues, T. E.
dc.contributor.authorGarcia, F.
dc.contributor.authorLouvison, M.
dc.contributor.authorPaula, C. R.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Santo Amaro
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSanta Cruz State University
dc.date.accessioned2014-05-27T11:22:43Z
dc.date.available2014-05-27T11:22:43Z
dc.date.issued2007-12-01
dc.description.abstractA major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity.en
dc.description.affiliationPhysics Institute University of São Paulo, São Paulo, SP
dc.description.affiliationUNISA University of Santo Amaro, São Paulo, SP
dc.description.affiliationESALQ University of São Paulo, Piracicaba, SP
dc.description.affiliationInstitute for Biomedical Sciences University of São Paulo, São Paulo, SP
dc.description.affiliationSão Paulo State University UNESP, Botucatu, SP
dc.description.affiliationMedical Physics Group Santa Cruz State University, Ilhéus, BA
dc.description.affiliationUnespSão Paulo State University UNESP, Botucatu, SP
dc.format.extent398-404
dc.identifierhttp://www.ans.org/store/i_700330
dc.identifier.citation8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07, p. 398-404.
dc.identifier.scopus2-s2.0-58349095158
dc.identifier.urihttp://hdl.handle.net/11449/70159
dc.language.isoeng
dc.relation.ispartof8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCell death
dc.subjectDNA
dc.subjectDosimetry
dc.subjectElectric field effects
dc.subjectElectric field measurement
dc.subjectElectric fields
dc.subjectGamma rays
dc.subjectGenes
dc.subjectLinear accelerators
dc.subjectNucleic acids
dc.subjectOrganic acids
dc.subjectQuantum optics
dc.subjectRadiotherapy
dc.subjectTheorem proving
dc.subjectBeam intensities
dc.subjectBiological responses
dc.subjectCancer therapies
dc.subjectCase studies
dc.subjectControlled conditions
dc.subjectDesign and constructions
dc.subjectDna damages
dc.subjectDna repairs
dc.subjectGamma radiation sources
dc.subjectGamma radiations
dc.subjectLethal doses
dc.subjectNew techniques
dc.subjectNormal tissues
dc.subjectProtein interactions
dc.subjectRadiation doses
dc.subjectTarget volumes
dc.subjectRadiation
dc.titleDeveloping new radiotherapy techniques using linac based gamma radiation sourcesen
dc.typeTrabalho apresentado em evento

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