Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia

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dc.contributor.authorCorrêa, Josilene Chaves Ruela [UNESP]
dc.contributor.authorHiene, Marcelo Augusto Cavaretti [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:27Z
dc.date.available2016-01-28T16:56:27Z
dc.date.issued2013
dc.description.abstractSodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil
dc.format.extent1-6
dc.identifierhttp://dx.doi.org/10.4172/2155-9872.1000177
dc.identifier.citationJournal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.
dc.identifier.doi10.4172/2155-9872.1000177
dc.identifier.fileISSN2155-9872-2013-05-01-01-06.pdf
dc.identifier.issn2155-9872
dc.identifier.lattes6036218587648028
dc.identifier.lattes9881720291571774
dc.identifier.lattes9543471795910202
dc.identifier.urihttp://hdl.handle.net/11449/133745
dc.language.isoeng
dc.relation.ispartofJournal of Analytical & Bioanalytical Techniques
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectMalignant hyperthermiaen
dc.subjectSodium azumoleneen
dc.subjectUV-VISen
dc.subjectSpectrophotometryen
dc.subjectLiquid chromatographyen
dc.subjectQuality controlen
dc.titlePhysico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermiaen
dc.typeArtigo
unesp.author.lattes6036218587648028
unesp.author.lattes9881720291571774
unesp.author.lattes9543471795910202
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Médicamentospt

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