A comparison of human and porcine acellular dermal tissues in the subcutaneous space of a rat model

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dc.contributor.authorHoyama, Erika [UNESP]
dc.contributor.authorSchellini, Silvana Artioli [UNESP]
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorRossa, Romualdo
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:21:41Z
dc.date.available2014-05-27T11:21:41Z
dc.date.issued2005-12-01
dc.description.abstractThe study compared the host response to a human and a porcine acellular dermal tissue implanted in the subcutaneous space of a rat model. The human and porcine acellular grafts were surgically implanted in the subcutaneous tissue of rats (5 rats/group) and the materials were evaluated at 7, 15, 30, 60 and 180 postoperative days (PO). The histological immune response was quantified using a digital image analysis system, which evaluated the number of vessels present in the implants and in the surrounding soft tissue, the area of inflammatory cell infiltration in the grafts, the width of the capsular formation present around the tissues and the area of implants absorbed. The data were submitted to statistical analysis. Light microscopy showed mononuclear cellular infiltration, the presence of a capsular formation surrounding the grafts and the presence of vacuolar structures (optically empty spaces) inside the implants. The image analysis comparing both materials showed significant inflammatory cells in the human graft at 15 and 30 PO, thicker capsular formation in the porcine tissue at 60 PO, increased number of vessels inside the implants and in the surrounding tissues in the porcine graft and a similar absorption pattern in both materials at 180 PO. The histological findings showed that both tissues were well-tolerated when implanted in the subcutaneous tissue of rats, allowing us to consider the porcine acellular dermal graft as a provisional alternative material for reconstructive plastic surgery. Copyright © 2005 Taylor & Francis LLC.en
dc.description.affiliationDepartment of Ophthalmology Faculdade de Medicina de Botucatu
dc.description.affiliationDepartment of Pathology Faculdade de Medicina de Botucatu
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery Universidade de São Paulo
dc.description.affiliationDepartment of Biostatistics Bioscience Institute Faculdade de Medicina de Botucatu
dc.description.affiliationDepartamento de OFT/ORL/CCP Faculdade de Medicina de Botucatu UNESP, Rubião Júnior, S/N, Cep: 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartment of Ophthalmology Faculdade de Medicina de Botucatu
dc.description.affiliationUnespDepartment of Pathology Faculdade de Medicina de Botucatu
dc.description.affiliationUnespDepartment of Biostatistics Bioscience Institute Faculdade de Medicina de Botucatu
dc.description.affiliationUnespDepartamento de OFT/ORL/CCP Faculdade de Medicina de Botucatu UNESP, Rubião Júnior, S/N, Cep: 18618-000 Botucatu, SP
dc.format.extent249-255
dc.identifierhttp://dx.doi.org/10.1080/01676830590930724
dc.identifier.citationOrbit, v. 24, n. 4, p. 249-255, 2005.
dc.identifier.doi10.1080/01676830590930724
dc.identifier.issn0167-6830
dc.identifier.issn1744-5108
dc.identifier.lattes9420249100835492
dc.identifier.lattes8727897080522289
dc.identifier.lattes7528116925519142
dc.identifier.scopus2-s2.0-29044446857
dc.identifier.urihttp://hdl.handle.net/11449/68516
dc.language.isoeng
dc.relation.ispartofOrbit
dc.relation.ispartofsjr0,419
dc.relation.ispartofsjr0,419
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAcellular dermal tissue
dc.subjectBiomaterials
dc.subjectHost vs. Graft response
dc.subjectHuman tissue
dc.subjectPorcine tissue
dc.subjectRats
dc.subjectReconstructive plastic surgery
dc.subjectabsorption
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectblood vessel
dc.subjectcell infiltration
dc.subjectcell vacuole
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectdermis
dc.subjectevaluation
dc.subjecthistology
dc.subjecthuman
dc.subjecthuman experiment
dc.subjecthuman tissue
dc.subjectimage analysis
dc.subjectimmune response
dc.subjectimplant
dc.subjectimplantation
dc.subjectinflammatory cell
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmononuclear cell
dc.subjectnonhuman
dc.subjectplastic surgery
dc.subjectpostoperative period
dc.subjectquantitative analysis
dc.subjectrat
dc.subjectskin graft
dc.subjectskin transplantation
dc.subjectsoft tissue
dc.subjectspecies comparison
dc.subjectstatistical analysis
dc.subjectsubcutaneous tissue
dc.subjectswine
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectGraft Survival
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectModels, Animal
dc.subjectSkin
dc.subjectSkin Transplantation
dc.subjectStatistics, Nonparametric
dc.subjectSubcutaneous Tissue
dc.subjectSwine
dc.titleA comparison of human and porcine acellular dermal tissues in the subcutaneous space of a rat modelen
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes9420249100835492
unesp.author.lattes8727897080522289[5]
unesp.author.lattes7528116925519142
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Bioestatística - IBB
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