Maternal-Fetal Outcome, Lipid Profile and Oxidative Stress of Diabetic Rats Neonatally Exposed to Streptozotocin

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dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorKiss, A. C. I. [UNESP]
dc.contributor.authorSinzato, Y. K. [UNESP]
dc.contributor.authorCampos, Kleber Eduardo de [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:23Z
dc.date.available2014-05-20T13:35:23Z
dc.date.issued2011-07-01
dc.description.abstractBackground: There is no evidence about the integrated issue on glycemia, lipid profile, oxidative stress, and anomaly frequency of pregnant diabetic rats neonatally exposed to streptozotocin.Objective: Evaluating the impact of hyperglycemia in diabetic rats neonatally exposed to streptozotocin on maternal reproductive and fetal outcomes and the relationship with lipid profile and maternal oxidative stress.Material and Methods: Ten 90-day-old female Wistar rats were mated to obtain offspring. Some of these newborns received streptozotocin (70 mg/kg, i.p. - n5-STZ group) and the remainder given only citrate buffer (control group) on their day 5 of life. At adult life, these rats (n =13 animals/group) were mated and, at day 21 of pregnancy, they were killed to obtain a maternal blood samples for biochemical determinations. The gravid uterus was weighed with its contents and fetuses were analyzed.Results: At day 0 of pregnancy, glycemic means of n5-STZ rats were significantly greater compared to those of control rats, but presented fetuses classified as small for pregnancy age. The n5-STZ rats showed increased total cholesterol, triglycerides, MDA concentrations, lower SOD activity and increased frequency fetal visceral anomalies as compared to the control group.Conclusion: This study showed that the experimental model used led to mild hyperglycemia during pregnancy, although it did not lead to increased macrosomic fetus rates. The hyperglycemic maternal environment caused metabolic alterations, including increased triglyceride and total cholesterol concentrations, and elevated oxidative stress, contributing to increase fetal visceral anomalies.en
dc.description.affiliationMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Barra do Garcas, Mato Grosso, Brazil
dc.description.affiliationSão Paulo State Univ Unesp, Dept Gynecol & Obstet, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, São Paulo, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Dept Gynecol & Obstet, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, São Paulo, SP, Brazil
dc.format.extent408-413
dc.identifierhttp://dx.doi.org/10.1055/s-0030-1269886
dc.identifier.citationExperimental and Clinical Endocrinology & Diabetes. Stuttgart: Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, v. 119, n. 7, p. 408-413, 2011.
dc.identifier.doi10.1055/s-0030-1269886
dc.identifier.issn0947-7349
dc.identifier.lattes6758680388835078
dc.identifier.lattes0679387622604743
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12167
dc.identifier.wosWOS:000294649600004
dc.language.isoeng
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetes
dc.relation.ispartofjcr1.623
dc.relation.ispartofsjr0,695
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmild diabetesen
dc.subjectstreptozotocinen
dc.subjectpregnancyen
dc.subjectoxidative stressen
dc.subjectanomalyen
dc.subjectraten
dc.titleMaternal-Fetal Outcome, Lipid Profile and Oxidative Stress of Diabetic Rats Neonatally Exposed to Streptozotocinen
dc.typeArtigo
dcterms.licensehttp://www.thieme.de/fz/_pdf/thieme_ir_policy_english.pdf
dcterms.rightsHolderJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh
unesp.author.lattes6758680388835078
unesp.author.lattes0679387622604743
unesp.author.lattes1490222400024738[2]
unesp.author.orcid0000-0002-4753-3264[7]
unesp.author.orcid0000-0003-4761-4336[6]
unesp.author.orcid0000-0002-9227-832X[5]
unesp.author.orcid0000-0002-7003-9643[1]
unesp.author.orcid0000-0002-8558-0141[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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