Physical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levels

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dc.contributor.authorNascimento, Carla Manuela Crispim [UNESP]
dc.contributor.authorPereira, Jessica Rodrigues [UNESP]
dc.contributor.authorAndrade, Larissa Pires de [UNESP]
dc.contributor.authorGaruffi, Marcelo [UNESP]
dc.contributor.authorTalib, Leda Leme
dc.contributor.authorForlenza, Orestes Vicente
dc.contributor.authorMaria Cancela, Jose
dc.contributor.authorCominetti, Marcia Regina
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Vigo
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2015-03-18T15:56:12Z
dc.date.available2015-03-18T15:56:12Z
dc.date.issued2014-01-01
dc.description.abstractThe benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines levels and to improve BDNF peripheral concentrations. The main goal of this research was to analyze the effects of a 16-week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis-alpha (TNF-alpha) and Interleukin-6 (IL-6) as pro-inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impairment (MCI). Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Thirty cognitively healthy participants and thirty-seven MCI participants were assigned to the control (CG) and trained (TG) groups. The TG participated in a multimodal physical training program for a 16-week period. The results showed a significant between-subjects interaction, which indicates the beneficial contribution of training on the reduction of TNF-alpha (p= 0.001) and IL-6 (p<0.001) and on the improvement of BDNF (p<0.001) peripheral concentrations. Cognitive functions also presented significant improvements for MCI trained group (p= 0.03). In conclusion, physical exercise was effective to reduce pro-inflammatory cytokines and to improve BDNF peripheral levels, with positive reflexes on cognition. To the best of our knowledge, this is the first study that evaluated longitudinally the effects of a multimodal physical exercises protocol on peripheral concentrations of pro-inflammatory cytokines and cognition performance in elderly MCI individuals.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Psiquiatria, BR-01060970 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Inst Psiquiatria, Lab Neurociencias LIM 27, BR-01060970 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-01060970 Sao Paulo, Brazil
dc.description.affiliationUniv Vigo, HealthyFyt Grp, Fac Ciencias Deporte, Vigo 36310, Spain
dc.description.affiliationUniv Fed Sao Carlos, Dept Gerontol, Lab Biol Envelhecimento LABEN, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 02/13633-7
dc.format.extent799-805
dc.identifierhttp://dx.doi.org/10.2174/156720501108140910122849
dc.identifier.citationCurrent Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 11, n. 8, p. 799-805, 2014.
dc.identifier.doi10.2174/156720501108140910122849
dc.identifier.issn1567-2050
dc.identifier.lattes7964386240653380
dc.identifier.urihttp://hdl.handle.net/11449/117458
dc.identifier.wosWOS:000342142600009
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Alzheimer Research
dc.relation.ispartofjcr3.289
dc.relation.ispartofsjr1,187
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgingen
dc.subjectcognitionen
dc.subjectinflammationen
dc.subjectinterleukin-6en
dc.subjectmild cognitive impairmenten
dc.subjectphysical activityen
dc.subjecttumor necrosis factor alphaen
dc.titlePhysical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levelsen
dc.typeArtigo
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.lattes7964386240653380
unesp.author.orcid0000-0001-6385-7392[8]
unesp.author.orcid0000-0002-8860-5818[3]
unesp.author.orcid0000-0003-2903-3829[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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