Determination of lomefloxacin in tablet preparations by liquid chromatography

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dc.contributor.authorTozo, Greci C. G.
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:30Z
dc.date.available2014-05-20T13:24:30Z
dc.date.issued2006-09-01
dc.description.abstractA sensitive, precise, and specific high-performance liquid chromatography (HPLC) method was developed for the assay of lomefloxacin (LFLX) in raw material and tablet preparations. The method validation parameters yielded good results and included the range, linearity, precision, accuracy, specificity, and recovery. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. The HPLC separation was performed on a reversed-phase Phenomenex C18 column (150 x 4.6 mm id, 5 pm particle size) with a mobile phase composed of 1% acetic acid-acetonitrile-methanol (70 + 15 + 15, v/v/v), pumped isocratically at a flow rate of 1.0 mL/min. The effluent was monitored at 280 nm. The calibration graph for LFLX was linear from 2.0 to 7.0 mg/mL. The interday and intraday precisions (relative standard deviation) were less than 1.0%. The method was applied for the quality control of commercial LFLX tablets to quantitate the drug.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Programa PosGrad Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Programa PosGrad Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.format.extent1305-1308
dc.identifierhttp://www.ingentaconnect.com/content/aoac/jaoac/2006/00000089/00000005/art00011
dc.identifier.citationJournal of Aoac International. Gaithersburg: Aoac International, v. 89, n. 5, p. 1305-1308, 2006.
dc.identifier.issn1060-3271
dc.identifier.urihttp://hdl.handle.net/11449/7624
dc.identifier.wosWOS:000240883600012
dc.language.isoeng
dc.publisherAoac International
dc.relation.ispartofJournal of AOAC International
dc.relation.ispartofjcr1.087
dc.relation.ispartofsjr0,324
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleDetermination of lomefloxacin in tablet preparations by liquid chromatographyen
dc.typeArtigo
dcterms.licensehttp://mc.manuscriptcentral.com/societyimages/aoac_jaoac/copyright.pdf
dcterms.rightsHolderAoac International
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR