Total intravenous anaesthesia in ponies using detomidine, ketamine and guaiphenesin: Pharmacokinetics, cardiopulmonary and endocrine effects

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dc.contributor.authorTaylor, P. M.
dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorSear, J. W.
dc.contributor.authorWheeler, M. J.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:01Z
dc.date.available2014-05-27T11:18:01Z
dc.date.issued1995-10-16
dc.description.abstractPharmacokinetics and some pharmacological effects of anaesthesia induced by a combination of detomidine, ketamine and guaiphenesin were investigated in eight ponies. Cardiopulmonary function was studied and plasma met-enkephalin, dynorphin, β-endorphin; arginine vasopressin, adrenocorticotrophin, cortisol, 11-deoxycortisol and catecholamine concentrations were measured. The combination produced slight cardiorespiratory depression, hyperglycaemia and a reduction in haematocrit. There were no changes in plasma opioids, pituitary peptides or catecholamines. Plasma cortisol concentration decreased and plasma 11-deoxycortisol increased indicating a suppression of steroidogenesis. Steady state ketamine and guaiphenesin concentrations were attained during the infusion period, and ketamine concentrations likely to provide adequate analgesia for surgical operations were achieved (more than 2.2 μg ml-1). Steady state detomidine concentration was not attained. The ponies took on average 68 minutes to recover to standing and the recovery was uneventful.en
dc.description.affiliationFaculdade de Medicina Veterinária E Zootecnia Universidade Estadual Paulista (UNESP) Campus de Botucatu, CEP 18618-000, Botucatu, Sao Paulo
dc.description.affiliationUnespFaculdade de Medicina Veterinária E Zootecnia Universidade Estadual Paulista (UNESP) Campus de Botucatu, CEP 18618-000, Botucatu, Sao Paulo
dc.format.extent17-23
dc.identifierhttp://dx.doi.org/10.1016/0034-5288(95)90024-1
dc.identifier.citationResearch in Veterinary Science, v. 59, n. 1, p. 17-23, 1995.
dc.identifier.doi10.1016/0034-5288(95)90024-1
dc.identifier.issn0034-5288
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.scopus2-s2.0-0029115494
dc.identifier.urihttp://hdl.handle.net/11449/64642
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectanesthetic agent
dc.subjectargipressin
dc.subjectcatecholamine
dc.subjectcorticotropin
dc.subjectcortodoxone
dc.subjectdetomidine
dc.subjectdynorphin
dc.subjectguaifenesin
dc.subjecthydrocortisone
dc.subjectketamine
dc.subjectmetenkephalin
dc.subjectanesthesia
dc.subjectcardiopulmonary insufficiency
dc.subjectcatecholamine blood level
dc.subjecthematocrit
dc.subjecthormone blood level
dc.subjecthormone release
dc.subjecthorse
dc.subjecthyperglycemia
dc.subjectintravenous drug administration
dc.subjectnonhuman
dc.subjectstanding
dc.subjectsteroidogenesis
dc.subjectAnesthesia, Intravenous
dc.subjectAnesthetics
dc.subjectAnesthetics, Dissociative
dc.subjectAnimal
dc.subjectDrug Interactions
dc.subjectEndocrine Glands
dc.subjectGuaiacol Glyceryl Ether
dc.subjectHemodynamics
dc.subjectHorses
dc.subjectHypnotics and Sedatives
dc.subjectImidazoles
dc.subjectKetamine
dc.subjectMale
dc.subjectRespiration
dc.subjectSupport, Non-U.S. Gov't
dc.subjectEquus caballus
dc.titleTotal intravenous anaesthesia in ponies using detomidine, ketamine and guaiphenesin: Pharmacokinetics, cardiopulmonary and endocrine effectsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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