Neonatal Gonocyte Differentiation in Mongolian Gerbil Meriones unguiculatus Involves Asynchronous Maturation of Seminiferous Cords and Rapid Formation of Transitional Cell Stage

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dc.contributor.authorPinto, Maria Etelvina
dc.contributor.authorBotta, Livia Silva [UNESP]
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.authorGoes, Rejane Maira [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:01:01Z
dc.date.available2014-05-20T14:01:01Z
dc.date.issued2010-02-01
dc.description.abstractThis study describes the neonatal differentiation of the Mongolian gerbil gonocytes, focusing on the relationship between its relocation to the basement membrane, apoptosis and postrelocation changes and also the distribution of androgen receptors (AR). Testes of gerbils from I to 35 days of age (d) were examined by high resolution light microscopy and immunocytochemistry for proteins PCNA, VASA, and AR as well as by the TUNEL method. Gonocytes were quantified according to degree of relocation into nonrelocated, relocating and relocated. Most of them were found in the center of seminiferous cords at 1 d but a small number of relocating and relocated gonocytes were already visible in the first postnatal day. After relocation, gonocytes change phenotypically to a transitional stage designated herein prospermatogonia. Both gonocyte relocation and transformation into spermatogonial lineage occur asynchronously in the seminiferous cords, mainly after 7 d. Gonocyte proliferation began before but peak after their relocation to basement membrane at the prospermatogonia stage. Higher levels of gonocyte apoptosis were found at 7 d and 21 d. From this time onward gonocytes were not found. Gonocytes and prospermatogonia showed high amounts of AR in their cytoplasm contrary to spermatogonial subtypes, indicating a possible AR inactivation in these cells. In conclusion, the process of gonocyte relocation in the gerbil extends until the second postnatal week, leads to their rapid differentiation into prospermatogonia and occurs simultaneously with the loss of androgen sensitivity. Differently from other laboratory rodents, the events regarding gonocyte maturation in the gerbil last longer and occur asynchronously in seminiferous cords. Anat Rec, 293:310319, 2010. (C) 2009 Wiley-Liss, Inc.en
dc.description.affiliationState Univ Campinas UNICAMP, Inst Biol, Dept Cell Biol, Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ IBILCE UNESP, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ IBILCE UNESP, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 12/069/2008-7
dc.description.sponsorshipIdFAPESP: 06-07008
dc.format.extent310-319
dc.identifierhttp://dx.doi.org/10.1002/ar.21050
dc.identifier.citationAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 293, n. 2, p. 310-319, 2010.
dc.identifier.doi10.1002/ar.21050
dc.identifier.issn1932-8486
dc.identifier.lattes1445259468526188
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21559
dc.identifier.wosWOS:000274702300014
dc.language.isoeng
dc.publisherWiley-liss
dc.relation.ispartofAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology
dc.relation.ispartofjcr1.373
dc.relation.ispartofsjr0,766
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectgonocytesen
dc.subjecttestisen
dc.subjectproliferationen
dc.subjectandrogen receptoren
dc.subjectMongolian gerbilen
dc.titleNeonatal Gonocyte Differentiation in Mongolian Gerbil Meriones unguiculatus Involves Asynchronous Maturation of Seminiferous Cords and Rapid Formation of Transitional Cell Stageen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-liss
unesp.author.lattes1445259468526188
unesp.author.lattes0947193347312157[4]
unesp.author.orcid0000-0002-2205-0864[1]
unesp.author.orcid0000-0002-0970-4288[3]
unesp.author.orcid0000-0002-3622-460X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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