Development and Validation of an UV-Derivative Spectrophotometric Method for Determination of Glimepiride in Tablets

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dc.contributor.authorBonfilio, Rudy [UNESP]
dc.contributor.authorde Araujo, Magali B.
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.date.accessioned2014-05-20T13:24:49Z
dc.date.available2014-05-20T13:24:49Z
dc.date.issued2011-02-01
dc.description.abstractGlimepiride is an oral antidiabetic drug widely used in treatment of type 2 diabetes. This work proposed the development and validation of a derivative UV spectrophotometric method for determination of glimepiride in tablets. The quantification of glimepiride in 5x10(-3) mol L(-1) NaOH was performed by using a wavelength interval of 8 nm in the range of 220-300 nm. The amplitude values obtained in the second-derivative spectra were arbitrary units of the peak height from the central zero base line to the signals obtained at 279.0, 257.5 and 256.3 nm for quantification of Amaryl (R) tablets 1 mg, Amaryl (R) tablets 2 mg and Amaryl (R) tablets 4 mg, respectively. The method was completely validated according to the International Conference on Harmonization (ICH) guidelines, showing accuracy, precision, selectivity, robustness and linearity. The validated method is suitable for quality control applications, since it does not use polluting reagents, it is simple and has low-cost.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmcos & Med, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Alfenas, Dept Farm, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmcos & Med, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.format.extent292-299
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532011000200015
dc.identifier.citationJournal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 22, n. 2, p. 292-299, 2011.
dc.identifier.doi10.1590/S0103-50532011000200015
dc.identifier.fileS0103-50532011000200015.pdf
dc.identifier.issn0103-5053
dc.identifier.scieloS0103-50532011000200015
dc.identifier.urihttp://hdl.handle.net/11449/7804
dc.identifier.wosWOS:000287990700015
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectglimepirideen
dc.subjectvalidation of pharmaceutical methodsen
dc.subjectderivative-UV spectrophotometryen
dc.subjectpharmaceutical quality controlen
dc.titleDevelopment and Validation of an UV-Derivative Spectrophotometric Method for Determination of Glimepiride in Tabletsen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica
unesp.author.orcid0000-0002-0385-340X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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